en Protective Effects of Vitamin C and Chitosan against Cadmium-Induced Oxidative Stress in the Liver of Common Carp (Cyprinuscarpio) عمومى General پژوهشي Research <b>Background: </b>Cadmium (Cd) intoxication can cause oxidative stress and involve the antioxi-dant defense system in hepatocytes. Administration of vitamin C, chitosan, or a combination of both may prevent Cd-induced oxidative damage. <br> <b>Methods:</b>Cyprinus carpio were distributed into six groups. The control group received normal feed (Group I). Group II was exposed to 0.2 mg.L-1 cadmium chloride. Group III were fed 1000 mg chitosan per 1 kg feed. Group IV was exposed to 0.2 mg.L-1 cadmium chloride and fed with1000 mg chitosan per 1 kg feed while Group V was exposed to 0.2 mg.L-1 cadmium chlo-ride and was fed with 1000 mg vitamin C per 1 kg feed. Group VI, however, was exposed to 0.2 mg.L-1 cadmium chloride and was fed with 1000 mg vitamin C combined with 1000 mg chi-tosanper 1 kg feed. After 21 days of experiment, activities of hepatic enzymes and oxidative stress biomarkers were evaluated. <br><b>Results:</b>Exposure to CdCl2 caused a significant increase in malondialdehyde levels and al-tered alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase activities in liver tissues. Hepatic antioxidant capacity, catalase, and Glucose-6-phosphate dehydrogenase activities significantly decreased in fishes exposed to CdCL2 as compared to the control group. Treatment with vitamin C and vitamin C combined with chitosan significantly ameliorated these changes. <br><b>Conclusion:</b>The present findings suggest that the administration of chitosan failed to restore biochemical parameters to normal levels. However, these findings demonstrate that vitamin C and vitamin C combined with chitosan protect the fish against the toxic effects of CdCl2 on the examined biochemical parameters in liver tissues. Cadmium, Chitosan, Hepatoprotective, Oxidative Stress, Vitamin C. Cadmium, Chitosan, Hepatoprotective, Oxidative Stress, Vitamin C. 1360 1367 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-225-6&slc_lang=en&sid=1 Milad Mehrpak میلاد مهرپاک 10031947532846004560 10031947532846004560 No Department of Aquaculture, Behbahan Khatam Alanbia University of Technology, Iran. Department of Aquaculture, Behbahan Khatam Alanbia University of Technology, Iran. Mahdi Banaee مهدی بنایی banaee@bkatu.ac.ir 10031947532846004561 10031947532846004561 Yes Department of Aquaculture, Behbahan Khatam Alanbia University of Technology, Iran. Department of Aquaculture, Behbahan Khatam Alanbia University of Technology, Iran. Behzad Nematdoost Haghi بهزاد نعمت دوست حقی 10031947532846004562 10031947532846004562 No Department of Aquaculture, Behbahan Khatam Alanbia University of Technology, Iran. Department of Aquaculture, Behbahan Khatam Alanbia University of Technology, Iran. Ahmad Noori احمد نوری 10031947532846004563 10031947532846004563 No Department of Aquaculture, Hormozgan University, Bandar Abbas, Iran. Department of Aquaculture, Hormozgan University, Bandar Abbas, Iran.