en Determining the complications, mortality, and treatment of patients hospitalized at Baharloo hospital due to oral hypoglycemic drugs toxicity in 2008-9 عمومى General پژوهشي Research <span style="font-weight: bold">Background:</span> Glybenclamide and metformin are two of the most common oral hypoglycemic drugs which are often used in treatment of type II diabetes mellitus. Toxicity due to these drugs may occur intentionally, accidentally, or even at the normal dosage because of the progression of such internal diseases as renal dysfunction. <br><span style="font-weight: bold">Methods:</span> In this case series study, 59 patients poisoned with oral hypoglycemic agents referring to Baharloo Hospital were evaluated between March 2009 and September 2010. <br><span style="font-weight: bold">Results:</span> The most common clinical findings were lethargy (66.7%) and drowsiness (66.7%) that were mostly observed in patients who had concomitantly ingested glybenclamide and metformin. Metabolic acidosis was observed in 33.3% of the patients who had ingested metformin alone and 22.2 % of the patients who had ingested metformin together with glybenclamide. Some degrees of hypoglycemia were observed in 50.8% of the patients upon admission nevertheless, severe hypoglycemia was seen only in 17% of them. The majority of the patients got improved within 3 days of hospitalization and got discharged. Although due to the severity of toxicity and its associated complications, 22.8% of the patients needed more than 3 days of hospitalization, permanent neurological complications and mortality did not happen to any of the patients. <br><span style="font-weight: bold">Conclusion:</span> Glybenclamide overdose leads to hypoglycemia and it can be prevented by careful monitoring of blood glucose and immediate treatment with intravenous dextrose, mostly occuring due to its hypoglycemic effects on the brain. Glybenclamide, metformin, oral hypoglycemic drugs, suicide, toxicity Glybenclamide, metformin, oral hypoglycemic drugs, suicide, toxicity 367 372 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-21&slc_lang=en&sid=1 Behnam Behnoosh بهنام بهنوش 10031947532846003254 10031947532846003254 No Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran Fakhrodin Taghdosi Nejad فخرالدین تقدسی نژاد 10031947532846003255 10031947532846003255 No Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran Mohammad Arefi محمد عارفی 10031947532846003256 10031947532846003256 No Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran Rasoul Roshani رسول روشنی roshani@razi.tums.ac.ir 10031947532846003257 10031947532846003257 Yes Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran Iran Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran Iran Mohammad Jamalian محمد جمالیان 10031947532846003258 10031947532846003258 No Department of Forensic Medicine, Arak University of Medical Sciences, Arak, Iran Department of Forensic Medicine, Arak University of Medical Sciences, Arak, Iran