en عمومى General پژوهشي Research <p><strong>Background:</strong> Pistachio is one of the main nutrients, not only as a strategic crop but also as a main type of nut, in Iranians&rsquo; food cycle. The aim of this study was to measure the relative safety of Iranian pistachio based on the standard pesticide&rsquo;s residue limits, which should be monitored and assessed in the cultivation of pistachio in order to confirm its public health.</p> <p><strong>Methods: </strong>Fifty samples of pistachios of different brands were collected from Tehran markets in 2015. QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) sampling method was used in order to determine the pesticide&rsquo;s residue in the pistachio nuts by Gas chromatography/Mass spectrometry (GC/MS).The method was validated with related parameters. Recovery took place at five concentration rates (n=3) ranging from 81.40% to 93.08% with the majority of RelativeStandard Deviation being lower than 20%. Limits of detection and quantification for all the pesticides were 2&micro;g/kg and10&micro;g/kg, respectively. The validated method seemed to be appropriate for the analysis of pesticide&rsquo;s residue in pistachio nuts. The pesticide&rsquo;s residue was analyzed in 50 pistachio samples obtained from different markets.</p> <p><strong>Results:</strong> Identified pesticides included fenitrothion, carbaryl and diazinon. Detectable pesticide&rsquo;s residue existed in 10% (5 samples) of the samples.</p> <p><strong>Conclusion:</strong> All the results were compared with the Iran&rsquo;s National Standards and the European Maximum Residue Limits. As compared to the acceptable daily intake, the calculated daily intake of each pesticide was much lower than the standard level, which could not cause any public health problem.</p> Pesticide residue, Pistachios, EDI, ADI, MRL Pesticide Residue, Pistachio, Risk Assessment, Strategic Crop 1 6 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-361-1&slc_lang=en&sid=1 Azadeh Emami 10031947532846005967 10031947532846005967 No MSc of Toxicology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Zahra Mousavi moosavi.z@iaups.ac.ir 10031947532846005968 10031947532846005968 Yes Department of Pharmacology & Toxicology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran. Vahid Ramezani 10031947532846005969 10031947532846005969 No PhD of Pharmaceutics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Shahram Shoeibi 10031947532846005970 10031947532846005970 No PhD of Food Chemistry, Food and Drug Laboratory Research Center, Tehran, Iran. Hossein Rastegar 10031947532846005971 10031947532846005971 No PhD of Pharmacology, Food and Drug Laboratory Research Center, Tehran, Iran. Maryam Amirahmadi 10031947532846005972 10031947532846005972 No PhD of Toxicology, Food and Drug Laboratory Research Center, Tehran, Iran. Iman Emami 10031947532846005973 10031947532846005973 No Department of Food Science and Technology, Yazd, Branch Islamic Azad University, Yazd, Iran.