Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1395
10
1
gregorian
2017
1
1
11
2
online
1
fulltext
en
Atrazine-Mediated Oxidative Stress Responses and Lipid Peroxidation in the Tissues of Clarias gariepinus
عمومى
General
پژوهشي
Research
<p><strong>Background:</strong> Fish have been at high risk of atrazine toxicity. Comparative atrazine toxicity on the tissues of <em>Clarias</em> <em>gariepinus</em> is scanty. Therefore, acute and chronic effects of atrazine on some biochemical parameters in <em>Clarias</em> <em>gariepinus</em> were investigated in this study.</p>
<p><strong>Methods:</strong> Atrazine toxicity was determined by assessing the responses of glucose, protein, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), superoxide dismutase (SOD), acetylcholinestarase (AChE) and malondialdehyde (MDA) in blood, gill and liver of fish exposed to both acute (0.00, 28.00, 30.00, 32.00 and 34.00 µg/l) and chronic (0.00, 7.00, 7.50, 8.00 and 8.50 µg/l) concentrations for 96 h and 28 d, respectively.</p>
<p><strong>Results:</strong> In acute exposure, glucose and MDA levels showed significant (<em>P</em><0.05) variations in all tissues. Protein and LDH decreased in all tissues except the latter slightly increased at 32.00µg/l in blood and liver compared to control. ALT and AChE were induced in blood but inhibited in gill and liver. SOD significantly decreased in blood but increased in gill and liver. AST was activated in blood and liver but reduced in gill. In chronic exposure, glucose, protein, SOD and AChE were inhibited in all tissues, while MDA level was induced. ALT, AST, and LDH activities were induced in blood but inhibited in gill and liver except 22.90% induction noted in liver at 8.00 µg/l atrazine.</p>
<p><strong>Conclusion:</strong> Exposure to varying concentrations of atrazine induced enzymatic/metabolic alterations in <em>C. gariepinus</em>. These alterations can be used as biomarkers of atrazine toxicity in fish.</p>
Atrazine, Clarias gariepinus, biochemical parameters, oxidative stress, Tissues
Atrazine, Biochemical parameters, Clarias gariepinus, Oxidative stress, Tissues
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http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-388-1&slc_lang=en&sid=1
Olufemi David
Owolabi
olulabi47@yahoo.com
10031947532846005904
10031947532846005904
Yes
Department of Zoology, University of Ilorin, Ilorin, Nigeria
James Sunday
Omotosho
10031947532846005905
10031947532846005905
No
Department of Zoology, University of Ilorin, Ilorin, Nigeria