en عمومى General پژوهشي Research <p><strong>Background:</strong> To explore the oral absorption of scorpion venom an ELISA were designed in this study. Scorpions and their venom were been used for centuries as medical treatments in traditional medicine. The oral administration of drug referred as the convenient way, as there was not any publication about gastro-intestinal absorption of scorpion venom; this experiment checked oral absorption of <em>Mesobuthus eupeus</em> scorpion venom in mice.</p> <p><strong>Methods:</strong> Six groups of mice orally received 0, 0.2, 0.5, 1, 2 and 5 mg/kg <em>of M. eupeus</em> venom and their blood samples were tacked after 15, 30, 60 min and 2, 4, 6, 24, 48 h after that. The presence of venom the blood samples were detected with a house- antigen capture ELISA.</p> <p><strong>Results:</strong> The venom was absorbed after its feeding to mice. The animals expressed no signs of envenomation and, the venom was detectable by AC-ELISA as soon as 15 min after its feed. M<em>aximum</em> serum <em>levels</em> were<em> 2</em> <em>h after</em> its meal.</p> <p><strong>Conclusion:</strong> The orally administrated venom was absorbed to the blood circulation without any clinically symptoms.</p> مزوبتوس اپئوس, زهر, عقرب, جذب خوراکی Mesobuthu Eupeus, Oral Absorption, Scorpion, Venom 15 19 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-418-1&slc_lang=en&sid=1 Zohreh Hosseini 10031947532846005894 10031947532846005894 No Student of Veterinary Medicine, Shahid Chamran University of Ahvaz, Iran. Mohammad Khosravi m.khosravi@scu.ac.ir 10031947532846005895 10031947532846005895 Yes Department of Pathobiology, Shahid Chamran University of Ahvaz, Iran. Masoud Ghorbanpoor 10031947532846005896 10031947532846005896 No Department of Pathobiology, Shahid Chamran University of Ahvaz, Iran. Mansour Mayahi 10031947532846005897 10031947532846005897 No Department of Clinical Sciences, Shahid Chamran University of Ahvaz, Iran.