en عمومى General پژوهشي Research <p><strong>Background:</strong> Mercury in any form is poisonous and mercury toxicity most commonly affects the nervous, gastrointestinal (GI) and urinary systems. The aim of this study was to investigate the specific effect associated with mercury toxicity and to evaluate the effectiveness of iron and vitamin B₆ supplement on mercury-induced toxicities in rats.</p> <p><strong>Methods:</strong> This experiment was performed on 25 rats. All rats were randomly divided into five equal groups (5&times;5). Toxic signs and body weight change, hematological parameters like total erythrocyte count (TEC), total leukocyte count (TLC), hemoglobin content (Hb%) and packed cell volume (PCV) and postmortem changes in rats were investigated.</p> <p><strong>Results:</strong> Rats treated with mercury intoxication showed severe toxic signs and significantly (<em>P</em><0.01) reduced TEC, TLC, Hb content and PCV. However, rats treated with mercury intoxication in combination with iron and vitamin B₆ showed physiological levels of hematological parameters. Mercury intoxication induced the congestion and necrosis in lung, liver, heart and kidney, whereas combined use of mercury intoxication, iron and vitamin B₆ recovered the condition.</p> <p><strong>Conclusion:</strong> Combined use of iron and vitamin B₆is highly protective against mercury toxicity.</p> Mercury Intoxication, Iron, Vitamin B6, Hematological Parameter Hematological Parameter, Iron, Mercury Intoxication, Vitamin B6 19 26 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-429-1&slc_lang=en&sid=1 Mohammad Taimur Islam shiplu_bau@yahoo.com 10031947532846006464 10031947532846006464 Yes Department of Pathobiology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh. Anup Kumar Talukder 10031947532846006465 10031947532846006465 No Department of Gynecology, Obstetrics and Reproductive Health, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh. Milton Talukder 10031947532846006466 10031947532846006466 No Department of Physiology and Pharmacology, Patuakhali Science and Technology University, Babugonj, Barisal, Bangladesh. Mohammad Rohul Amin 10031947532846006467 10031947532846006467 No Department of Physiology and Pharmacology, Patuakhali Science and Technology University, Babugonj, Barisal, Bangladesh. Khondoker Jahengir Alam 10031947532846006468 10031947532846006468 No Department of Pathology and Parasitology, Patuakhali Science and Technology University, Babugonj, Barisal, Bangladesh. Mohammad Golam Haider 10031947532846006469 10031947532846006469 No Department of Pathobiology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.