en عمومى General پژوهشي Research <strong>Background:</strong> <em>Heliotropium indicum</em> is used by traditional medical practitioners in North Central Nigeria for the management of ailments including diabetes. However, the folkloric use of <em>H. indicum</em> as antidiabetic has been asserted, but its roles on the hyperglycemia-induced organ-specific complications are not yet scientifically proven. Thus, ameliorative effect of aqueous leaf extract of <em>H. indicum</em> on selected toxicological parameters in hyperglycaemic rats was investigated in this study.<br> <strong>Methods:</strong> Twenty-five rats were randomized into five groups. The study was carried out at the Animal Holding Unit, Biochemistry Department, University of Ilorin in 2013. Four groups were intraperitoneally administered singly with 150 mg/kg b.wt of alloxan to induce hyperglycemia. The normal control (NC) and hyperglycaemic control (HC) groups were administered 1 ml distilled water, while the reference group (HR) were administered 14.2 mg/kg b.wt of metformin and the test groups, H30 and H75 were administered 30 and 75 mg/kg b.wt, the extract respectively for fourteen days.<br> <strong>Results:</strong> The significantly increased <em>(P</em><0.05) serum concentrations of tissue membrane bound enzymes (ALT, AST, ACP and ALP), direct and total bilirubin, urea and creatinine in HC indicating compromised tissue structures and functions in HC were attenuated. The significantly (<em>P</em><0.05) reduced serum total protein, globulin and albumin in HC were significantly increased by both doses of the extract. The ameliorative role of the extract at the test doses was supported by the histological assessment of liver and kidney of the animals.<br> <strong>Conclusion:</strong> Aqueous leaf extract of <em>H. indicum</em> can be explored at the ethnobotanical dose of 30 and 75 mg/kg b.wt on the management of some of the tissue-specific disarrays associated with diabetes. Hyperglycemia,Phytomedicine,Heliotropium indicum,Kidney Function,Liver Function Heliotropium Indicum, Hyperglycaemia, Kidney Function, Liver Function, Phytomedicine 19 26 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-455-1&slc_lang=en&sid=1 Rasheed Bolaji Ibrahim ibrahimrasheedb@gmail.com 10031947532846006747 10031947532846006747 Yes Department of Biochemistry, Faculty of Pure and Applied Sciences, Kwara State University, Malete, Ilorin, Nigeria. Jubril Olayinka Akolade 10031947532846006748 10031947532846006748 No PhD of Biochemistry, Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex, Sheda, Abuja, Nigeria. Abdulhakeem Olarewaju Sulyman 10031947532846006749 10031947532846006749 No Department of Biochemistry, Faculty of Pure and Applied Sciences, Kwara State University, Malete, Ilorin, Nigeria. Saheed Sabiu 10031947532846006750 10031947532846006750 No Department of Biochemistry, Faculty of Pure and Applied Sciences, Kwara State University, Malete, Ilorin, Nigeria. Babalola Ola Yusuf ybabalola16@gmail.com 10031947532846006751 10031947532846006751 No Department of Biochemistry, Faculty of Life Sciences, University of Ilorin, Ilorin, Nigeria. Lateefah Badrudeen Yusuf opeyemibadrudeen@gmail.com 10031947532846006752 10031947532846006752 No Department of Biochemistry, Faculty of Pure and Applied Sciences, Kwara State University, Malete, Ilorin, Nigeria.