en Modulating Role of Panax Ginseng in Phase - II Reaction of Hepato - Biotransformation in Albino Rats Following Mercuric Chloride Intoxication عمومى General پژوهشي Research <span style="font-weight: bold">Introduction:</span> The fate of xenobiotics that is present, increasing day by day. The increasing fates altered or inhibit the metabolic activities like detoxification and biotransformation. <br><span style="font-weight: bold">Methods:</span> The present study highlights this slow biotransformation and detoxification on the basis of specific enzymes which have a say in assessment of mercuric chloride toxicity and modulation by Panax ginseng root extract. <br><span style="font-weight: bold">Results:</span> The results revealed that mercuric chloride caused significant increase in liver weight, glutathione - s - transferase (GST), glutathione peroxidase (GPX), glutathione reductase (GR) and significant decrease in glutathione (GSH) level, while Panax ginseng alone and combination with mercuric chloride caused significant decrease in liver weight, glutathione - s - transferase (GST), glutathione peroxidase (GPX), glutathione reductase (GR) and glutathione (GSH) level. <br><span style="font-weight: bold">Conclusion:</span> The results suggest a modulating role of this root powder extract against raised enzyme levels and liver weight induced by mercuric chloride in albino rat Liver Weight, Glutathione -STransferase, Glutathione Peroxidase, Glutathione Reductase, Glutathione Liver Weight, Glutathione -STransferase, Glutathione Peroxidase, Glutathione Reductase, Glutathione 273 280 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-39&slc_lang=en&sid=1 Kanhiya Mahour Kanhiya Mahour kris_mathura@yahoo.com 10031947532846003319 10031947532846003319 Yes Toxicology Laboratory, Department of Zoology, School of Life Sciences, Khandari Campus Dr.B.R.Ambedkar University, Agra, India Toxicology Laboratory, Department of Zoology, School of Life Sciences, Khandari Campus Dr.B.R.Ambedkar University, Agra, India Prabhu N Saxena Prabhu N Saxena 10031947532846003320 10031947532846003320 No Toxicology Laboratory, Department of Zoology, School of Life Sciences, Khandari Campus Dr.B.R.Ambedkar University, Agra, India Toxicology Laboratory, Department of Zoology, School of Life Sciences, Khandari Campus Dr.B.R.Ambedkar University, Agra, India