Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1396
11
1
gregorian
2018
2
1
12
2
online
1
fulltext
en
In Vivo Assessment of Gamma Rays, Electron-beam Irradiation plus a Commercial Toxin Binder (Milbond-TX) As an Anti-Aflatoxin B1 in a Chicken Model
عمومى
General
پژوهشي
Research
<strong>Background:</strong> <em>Aspergillus flavus</em> is the most important fungus for production of Aflatoxin B1 (AFB1). This study evaluated the ability of gamma rays (GRs) and electron-beam irradiation (EBI) to counteract the deleterious effects of aflatoxin B1 (AFB1) in a chicken model.<br>
<strong>Methods:</strong> Overall, 168 one-day-old male Coturnix quails were assigned to eight treatments for 42 d in Tehran, Iran, in 2010 and 2011. Two dietary inclusion rates of AFB1 (0 and 2 ppm) and toxin binders, such as 0, 27 kGy doses of GRs, 27 kGy doses of EBI, and 0.3% of commercial toxin binder-milbond-TX, were tested in a 2×4 factorial manner. Serum biochemical parameters, immune response, and dietary treatments on factors associated with kidney and lipid profiles were determined on day 42.<br>
<strong>Results:</strong> AFB1 significantly decreased the hematological parameters (Hematocrit in 21 and 42 d), immune response (White blood cell (WBC), heterophil to lymphocyte ratio (H/L) and sheep red blood cell (SRBC)), and blood chemical factors (glucose, albumin, total protein, and triglycerides) compared to the control diet (<em>P</em><0.05). It also significantly increased the calcium, phosphorus, uric acid, and low-density lipoprotein (LDL) levels (<em>P</em><0.05). The addition of toxin binders, such as GRs, EBI, and milbond-TX, in the contaminated diets significantly diminished the inhibitory effects of dietary AFB1 (<em>P</em><0.05) on the hematological parameters, immune response, blood chemical factors, and factors associated with kidney and lipids profile with no differences compared to the control diet.<br>
<strong>Conclusion:</strong> The addition of these toxin binders may reduce the adverse effects produced by the presence of AFB1 in Japanese quails’ diets.
Aflatoxin B1, Electron-Beam Irradiation, Gamma Rays, Japanese Quail, Milbond-TX
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http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-65-3&slc_lang=en&sid=1
Saeed
Hasanpour
10031947532846007281
10031947532846007281
No
Department of Poultry Science, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.
Shaban
Rahimi
10031947532846007282
10031947532846007282
No
Department of Poultry Science, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.
Omid
Fani Makki
ofanimakki@birjand.ac.ir
10031947532846007283
10031947532846007283
Yes
MSc of Poultry Science, Research and Development Office, Zarin Gostar Sarina Company, Kashmar, Iran.
Gholamreza
Shahhosseini
10031947532846007284
10031947532846007284
No
Department of Agricultural Research, Medicine and Industrial Research School, Karaj, Iran.
Alireza
Khosravi
10031947532846007285
10031947532846007285
No
Department of Mycology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.