en عمومى General پژوهشي Research <strong>Background:</strong> Bisphenol A (BPA) has received attention in environmental and toxicological research due to its widespread effects in biological systems. While several anti-oxidants have been used in ameliorating BPA-induced toxicities in experimental animals, there is the scarcity of research information on the use of Gallic acid (GA) in protecting against BPA-induced toxicity. This study investigated the ameliorative effect of Gallic acid in BPA-induced toxicities of the adult male Wistar rats.<br> <strong>Methods:</strong> Thirty two adult male Wistar rats were randomly assigned into four groups of eight animals each as follows: Group 1 (Control rats): 0.2 ml of corn oil; Group 2 (GA-treated rats): 20 mg/kg/day GA (dissolved in distilled water); Group 3 (BPA-treated rats): 10 mg/kg/day BPA suspended in 0.2 ml corn oil; Group 4 (BPA+GA-treated rats): BPA (10 mg/kg/day) with a concomitant GA (20 mg/kg/day). All treatments were orally administered for 14 days.<br> <strong>Results:</strong> BPA significantly increased (<em>P</em><0.05) in the values of liver function enzymes (ALP, AST, ALT, GGT), total globulin, conjugated globulin, triglycerides, total cholesterol, low-density lipoprotein, creatinine, and urea as well as sodium ions. Concomitant treatment with GA ameliorated these elevated values. Moreover, BPA-induced histopathological alterations in the liver and kidney while GA ameliorated them.<br> <strong>Conclusion:</strong> BPA caused structural and cellular perturbations of the blood, liver, and kidney of rats while concomitant treatment with GA ameliorates the condition. Hence, GA has hepato-protective and nephroprotective actions against BPA-induced toxicity in Wistar rats. Bisphenol A, Gallic acid, Kidney, Liver, Toxicity 11 18 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-519-1&slc_lang=en&sid=1 Eunice Olufunke Ola-Davies ooladavies@yahoo.com 100319475328460011262 100319475328460011262 Yes Department of Veterinary Physiology and Biochemistry, University of Ibadan, Ibadan, Nigeria. Samuel Gbadebo Olukole 100319475328460011263 100319475328460011263 No Department of Veterinary Anatomy, University of Ibadan, Ibadan. Nigeria. Damilare Olaniyi Lanipekun 100319475328460011264 100319475328460011264 No Department of Veterinary Anatomy, University of Ibadan, Ibadan. Nigeria.