en عمومى General پژوهشي Research <strong>Background:&nbsp;</strong>We evaluated ameliorative effects of Jamun seed and orange peel extracts on liver toxicity in cypermethrin exposed rat.<br> <strong>Methods:</strong> Rats were given following treatments daily for 30 d:<br> Group A: Control<br> Group B: Rats received cypermethrin<br> Group C: These rats received cypermethrin and Jamun seed extract simultaneously<br> Group D: These rats received cypermethrin and orange peel extract simultaneously<br> Group E: Rats received orange peel extract<br> Group F: Rats received Jamun seed extract<br> In respective groups dose of cypermethrin, Jamun seed and orange peel extract were 25 mg/ kg body wt, 200 mg/kg body wt and 200 mg/kg body wt, respectively. Liver was fixed for light and electron microscopic studies.<br> <strong>Results:</strong> After 15 d cypermethrin or cypermethrin+JSE or cypermethrin+OPE treatment hepatocytes exhibited increased cell size, nuclei became more hyperchromatic and hypertrophied. Degeneration of nuclei and dilatation of sinusoids have been noticed. After 30 d cypermethrin treatment hepatocytes exhibit more pronounced hypertrophy with hyperchromatic nuclei. Few hepatocytes exhibit nuclei with irregular boundaries. Hepatocytes show foamy cytoplasm and few vacuoles. Focal necrosis visible at certain places. Binucleated cells are also encountered. In cypermethrin+JSE and cypermethrin+OPE treated rats, hepatocytes exhibit hypertrophy, hyperchromatic nuclei and dilatation of sinusoids. Degeneration of hepatocytes are seen at some places, however, focal necrosis is not seen in these groups. No noticeable histological alterations are seen in orange peel extract (group E) and jamun seed extract (group F) treated rats.<br> <strong>Conclusion:</strong> Cypermethrin induced hepatic toxicity can be protected by treatment with Jamun seed and orange peel extract. Cypermethrin, Hepatocytes, Pyrethroid, Jamun Seed Extract, Liver, Orange Peel Extract Liver 25 30 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-74-7&slc_lang=en&sid=1 Babita Deep Srivastava 100319475328460011285 100319475328460011285 No Department of Zoology, DDU Gorakhpur University, Gorakhpur, India. Manish Srivastava 100319475328460011286 100319475328460011286 No Department of Chemistry, Digvijai Nath P.G. College, Gorakhpur, India. Sunil Kumar Srivastav 100319475328460011287 100319475328460011287 No Department of Zoology, DDU Gorakhpur University, Gorakhpur, India. Nobuo Suzuki 100319475328460011288 100319475328460011288 No PhD of Environmental Toxicology, Institute of Nature and Environmental Technology, Kanazawa University, Ogi, Noto-cho, Ishikawa, Japan. Ajai Kumar Srivastav ajaiksrivastav@hotmail.com 100319475328460011289 100319475328460011289 Yes Department of Zoology, DDU Gorakhpur University, Gorakhpur, India.