en Pentoxifylline Attenuates Malathion-Induced Oxidative Damage in Rat عمومى General پژوهشي Research <span style="font-weight: bold">Introduction: </span>Toxic effects of pesticides are commonly associated with reactive oxygen species damage and pentoxifylline a phosphodiesterase inhibitor is a drug well known for antioxidant properties. The purpose of this study was to evaluate the oxidative damages following a subacute exposure to malathion, an organophosphorus insecticide and pentoxifylline's ability to counteract these effects. <br><span style="font-weight: bold">Material and Methods:</span> Malathion (200 mg/kg/day) and pentoxifylline (50 mg/kg/day) alone or in combination were administered intraperitoneally to rats and after one week, total antioxidant capacity (TAC) and total thiol groups (TTG) were measured in their blood. <br><span style="font-weight: bold">Results:</span> Pentoxifylline increased total antioxidant capacity (TAC) and total thiol groups (TTG) in blood significantly compared to malathion which decreased them. <br><span style="font-weight: bold">Conclusion:</span> Our findings suggest that oxidative stress occurs in exposure to malathion and oxidative damage may be a contributory factor in complications associated with malathion. The results indicate that malathion exposure decreases TAC and TTG, a process involved in oxidative stress and pentoxifylline could prevent this damage. Malathion, Oxidative Stress, Pentoxifylline, Antioxidants Analysis, Rats Malathion, Oxidative Stress, Pentoxifylline, Antioxidants Analysis, Rats 211 215 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-45&slc_lang=en&sid=1 Akram Ranjbar اکرم رنجبر a.rangbar@yahoo.com 10031947532846003335 10031947532846003335 Yes Department of Toxicology, Hamedan University of Medical Sciences, H amedan, Iran Department of Toxicology, Hamedan University of Medical Sciences, H amedan, Iran Rezvan Salehidoost رضوان صالحی دوست 10031947532846003336 10031947532846003336 No Shariati Hospital Tehran University of Medical sciences, Tehran. Iran Shariati Hospital Tehran University of Medical sciences, Tehran. Iran Maryam Baeeri مریم بعیری 10031947532846003337 10031947532846003337 No Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center Mohammad Abdollahi محمد عبدالهی 10031947532846003338 10031947532846003338 No Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center