en عمومى General پژوهشي Research <strong>Background:</strong> <em>Turraea vogelii</em> has been used as traditional medicine for the treatment of ailments including wounds, stomach aches, malaria, infections, filariasis cutaneous, among others and, it serves as source of food. The present study aimed to evaluate the nutraceuticals content and topical anti-inflammatory effect of hydro-methanol twig extract of <em>Turraea vogelii </em>(METV).<br> <strong>Method:</strong> METV was obtained using cold maceration with water and methanol in ratio 30:70. The concentration of vitamins A, C and E, total phenolic and total flavonoid contents were evaluated by UV spectrophotometric method. Phenol and xylene-induced ear edema was used to evaluate the topical anti-inflammatory effect in mice.<br> <strong>Results:</strong> The concentration of vitamins A, C and E was found to be 0.113 0.006, 9.303 0.012 and 0.020 0.001 mg in 100g of dried plant materials, respectively. Total phenolic and flavonoid contents were 0.281 0.318 mg/g gallic acid equivalent and 0.112 &nbsp;mg/g quercetin equivalent, respectively. Topical application of METV at a dose of 25 and 50mg/ear in xylene-induced ear edema produced significant inhibition (P<0.05) of 33 and 54% while in phenol-induced ear edema was significantly (P< 0.05) reduced by 44% and 34%. Dexamethasone (0.1mg/ear) produced an inhibition of 83% and 57% in phenol-induced ear edema.<br> <strong>Conclusion</strong>: Results from this study demonstrated that <em>Turraea vogelii</em> twigs contain flavonoids and phenolic compounds, which may be responsible for the topical anti-inflammatory effect of the plant extract. Anti-Inflammatory Effect, Dexamethasone, Phenol, Topical, Turraea Vogelii Extract, Xylene 35 39 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-561-1&slc_lang=en&sid=1 Hidayah Ayodeji Olumoh-Abdul ayodeji.ah@unilorin.edu.ng 100319475328460011379 100319475328460011379 Yes Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria. Rashidat Oluwafunke Ayanniyi 100319475328460011380 100319475328460011380 No Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria. Fatimoh Idowu Ojuade 100319475328460011381 100319475328460011381 No Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria. Remilekun Justina Agbana 100319475328460011382 100319475328460011382 No Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria.