en Evaluation of Anticonvulsant Effects of Nimodipine and Ascorbic Acid on Pentylenetetrazole- Induced Seizures in Mice عمومى General پژوهشي Research <span style="font-weight: bold">Introduction: </span>The mechanisms underlying the vulnerability of the brain to seizures remains unknown. Calcium ions influx and oxidative stress have been implicated in a variety of acute and chronic epileptogenic conditions. The present study was aimed at investigating the effects of nimodipine and ascorbic acid (vitamin C) alone and in combination on pentylenetetrazole (PTZ) - induced seizures in mice. <br><span style="font-weight: bold">Material and methods:</span> The animals received nimodipine (0.5, 1, 1.5, 2 mg/Kg, i.p.), ascorbic acid (30, 100, 300 mg/Kg, i.p.) alone and in combination with sodium valproate (100 mg/Kg, i.p.), 15 and 30min prior to intra-peritonral injection of PTZ (60 mg/Kg) and the acute seizure parameters such as seizure latency, duration and protection percent were studied in each group. <br><span style="font-weight: bold">Results:</span> Ascorbic acid alone did not have any effects on the seizure parameters and the number of mice convulsing ( P>0.05). Nimodipine in 2 mg/kg dose had full protective effect on PTZ- induced seizure parameters, and in lesser doses it exerted partial protective effects. The combination of ascorbic acid (300 mg/Kg) with nimodipine (1.5 mg/Kg) or sodium valproate had a significant synergistic protective effect against PTZ- induce seizures in comparison with controls( P<0.001). <br><span style="font-weight: bold">Conclusion:</span> Ascorbic acid potentiates the anticonvulsive effects of nimodipine on PTZ-induced seizure in mice. Nimodipine, Ascorbic acid, Pentylenetetrazole, Seizures, Mice Nimodipine, Ascorbic acid, Pentylenetetrazole, Seizures, Mice 221 227 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-47&slc_lang=en&sid=1 Kambiz Soltaninejad کامبیز سلطان نژاد kamsoltani@yahoo.com 10031947532846003343 10031947532846003343 Yes Department of Forensic Toxicology, Legal Medicine Organization of Iran, Tehran, Iran Department of Forensic Toxicology, Legal Medicine Organization of Iran, Tehran, Iran Shahin Shadnia شاهین شادنیا 10031947532846003344 10031947532846003344 No Loghman-Hakim Hospital Poison Center and Toxicology Resaerch Center,Faculty of Medicine, Shahid Beheshit Medical Sciences University, Tehran, Iran Loghman-Hakim Hospital Poison Center and Toxicology Resaerch Center,Faculty of Medicine, Shahid Beheshit Medical Sciences University, Tehran, Iran Fatemeh Hasaninejad فاطمه حسنی نژاد 10031947532846003345 10031947532846003345 No Department of Toxicology, and Pharmacology,Faculty of Pharmacy, Islamic Azad University, Tehran, Iran Department of Toxicology, and Pharmacology,Faculty of Pharmacy, Islamic Azad University, Tehran, Iran Friba Jabbari فریبا جابری 10031947532846003346 10031947532846003346 No Department of Toxicology, and Pharmacology,Faculty of Pharmacy, Islamic Azad University, Tehran, Iran Department of Toxicology, and Pharmacology,Faculty of Pharmacy, Islamic Azad University, Tehran, Iran Mohammad Abdollahi محمد عبدالهی 10031947532846003347 10031947532846003347 No Department of Toxicology, and Pharmacology,Faculty of Pharmacy; and Pharmaceutical Sciences Research Center.Tehran Medical Sciences University, Tehran, Iran Department of Toxicology, and Pharmacology,Faculty of Pharmacy; and Pharmaceutical Sciences Research Center.Tehran Medical Sciences University, Tehran, Iran