en Alteration of Serum Levels of Interlukin 1 and Tumor Necrosis Factor in Depression Independent of Treatment or Overdose of Tricyclic Antidepressants عمومى General پژوهشي Research <span style="font-weight: bold">Introduction:</span> Pro-inflammatory cytokines, such as IL-1b and TNF- α have been suggested to be involved in the pathophysiology of depression. Tricyclic antidepressants (TCAs) are also thought to influence immune functions and concentrations of cytokines. The aim of this study was to evaluate the status of serum IL-1b and TNF-α in depressed patients who were treated, not treated, or poisoned with TCAs in comparison to healthy subjects. <br><span style="font-weight: bold">Material & Methods:</span> In this cross-sectional study, 40 patients who were admitted at Loghman-Hakim Hospital from August 2007 to January 2008 were selected. They were divided into 4 groups: healthy individuals, TCA-poisoned patients, TCA-treated depressed patients, and non-treated depressed patients with 10 subjects in each group. Serum level of IL-1b and TNF-α were compared between groups and demographic and clinical data were collected by a questioner filled out by a trained practitioner. Liver function tests, blood cell count, electrocardiography, and arterial blood gases were also performed. <br><span style="font-weight: bold">Results:</span> Complete blood analysis and demographic data showed significant differences between groups. IL-1b level was higher among females. The group of depressed patients non-treated with TCAs showed higher serum concentrations of IL-1b and TNF-α than other groups. No significant difference was observed in IL-1b and TNF-α values among healthy control, depressed TCA-treated, and TCA-poisoned groups. <br><span style="font-weight: bold">Conclusion:</span> Depression and gender may influence the production of cytokines while neither TCAs treatment nor its overdose affects IL-1b and TNF-α. Tricyclic Antidepressants, Poisoning, Interleukins, Tumor Necrosis Factor-alpha, Cytokines Tricyclic Antidepressants, Poisoning, Interleukins, Tumor Necrosis Factor-alpha, Cytokines 228 233 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-48&slc_lang=en&sid=1 Hale Talaie هاله طالایی talaie@sbmu.ac.ir 10031947532846003348 10031947532846003348 Yes Toxicological ResearchCenter, Longhman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Toxicological ResearchCenter, Longhman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Abdollahi محمد عبدالهی 10031947532846003349 10031947532846003349 No Faculty of Pharmacy, and Phramaceutical sciences Research Center, Tehran University of Medical Sciences,Tehran, Iran Faculty of Pharmacy, and Phramaceutical sciences Research Center, Tehran University of Medical Sciences,Tehran, Iran Abdolkarim Pajoumand عبدالکریم پژومند 10031947532846003350 10031947532846003350 No Toxicological ResearchCenter, Longhman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Toxicological ResearchCenter, Longhman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Reyhaneh Panahandeh ریحانه پناهنده 10031947532846003351 10031947532846003351 No Toxicological ResearchCenter, Longhman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Toxicological ResearchCenter, Longhman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Behjat Barari بهجت براری 10031947532846003352 10031947532846003352 No Poison Center, Loghman-Hakim Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran Poison Center, Loghman-Hakim Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran Maryam Baeeri مریم بایری 10031947532846003353 10031947532846003353 No Faculty of Pharmacy, and Phramaceutical sciences Research Center, Tehran University of Medical Sciences,Tehran, Iran