en Sub Acute Toxicity of Aceclofenac Drug in Albino Rat عمومى General پژوهشي Research <span style="font-weight: bold">Introduction:</span> Nonsteroidal anti-inflammatory drugs are the most commonly used drugs to reduce pain and inflammation. Aceclofenac is a newer derivative of diclofenac with less gastrointestinal complications. The objective of the present study was to evaluate the toxicity profile of sustain release aceclofenac injection in rats at three dose levels, ranging from 2 to 10 mg/kg body weight. <br><span style="font-weight: bold">Material & Methods:</span> 48 Swiss albino rats were divided into four groups and were treated with saline or drug at three different doses for 28 days. Various physiological, hematological and biochemical parameters were studied. <br><span style="font-weight: bold">Results:</span> There were no mortality and signs of toxicity at different dose levels in any of the treatment groups. Hematological as well as biochemical parameters were unaffected at three different dose levels of aceclofenac sustain release injection. <br><span style="font-weight: bold">Conclusion:</span> These results indicated that aceclofenac injection is non-toxic even at higher dose level. Aceclofenac, Delayed-Action Preparations, Acute Toxicity Test, Anti Inflammatory Agents, Non Steroidal, Hematological Tests, Biochemical Phenomena Aceclofenac, Delayed-Action Preparations, Acute Toxicity Test, Anti Inflammatory Agents, Non Steroidal, Hematological Tests, Biochemical Phenomena 240 245 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-50&slc_lang=en&sid=1 Anupama Tamta Anupama Tamta 10031947532846003358 10031947532846003358 No Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India Anurag Payasi Anurag Payasi 10031947532846003359 10031947532846003359 No Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India Manu Chaudhary Manu Chaudhary 10031947532846003360 10031947532846003360 No Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India Adnan Ahmed Adnan Ahmed 10031947532846003361 10031947532846003361 No Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India Vivek Kumar Dwivedi Vivek Kumar Dwivedi vivekdwivedi@venusremedies.com 10031947532846003362 10031947532846003362 Yes Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India Intellectual Scientific Divison, R&D Center, Venus Medicine Research Center Baddi, India