Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1398
7
1
gregorian
2019
10
1
13
4
online
1
fulltext
en
Eryngium Bungei Boiss Extract Has Hepatoprotective Effect Against Liver Damage Induced by Acetaminophen in Rats: Novel Antioxidant and Anti-Inflammatory Effects
عمومى
General
پژوهشي
Research
<strong>Background</strong>: Acetaminophen-induced toxicity is a common cause of acute liver failure. This study investigated the hepatoprotective effects of <em>Eryngium bungei B</em>oiss (EB) extract against the hepatotoxicity in rats.<br>
<strong>Methods</strong>: Thirty adult male rats were randomly assigned to five groups, with free access to water and food. They were treated as follows: <em>Group 1</em> (negative controls): distilled water (DW); <em>Group 2</em> (positive controls): DW for 7 days and a single dose of 500 mg/kg BW acetaminophen orally on day 8<sup>th</sup>; <em>Groups 3, 4 </em>and<em> 5</em> (experimental groups): received EB extract mixed in DW at 100, 200 and 400 mg/kg/day orally for 7 days plus 500 mg/kg acetaminophen on the 8<sup>th</sup> day. On the 9thday, blood and liver samples were collected from all rats.<br>
<strong>Results</strong>: The EB extract improved the adverse histological changes in the rats’ livers and resulted in reduced serum ALT and ALP enzymes. Oxidative stress was noted in the liver tissue in <em>Group 2</em>. Pretreatment with EB extract reduced MDA concentration and increased GSH levels, compared to that for <em>Group 2</em>. The extract at 200 and 400 mg/kg/day significantly increased SOD activity, compared to that for <em>Group 2</em>. The IL-1β and TNF-α levels increased significantly in <em>Group 2</em>, compared to those in <em>Group 1</em>. Administration of EB extract in Groups 3, 4 and 5 significantly decreased the IL-1β and TNF-α parameters.<br>
<strong>Conclusions</strong>: The hepatoprotective effects of EB extract appears to be linked to its glutathione-mediated detoxification, free radical scavenging and anti-inflammatory properties.
Acetaminophen Hepatotoxicity, Eryngium Bungei Extract, Inflammation, Oxidative Stress, Rats
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http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-604-1&slc_lang=en&sid=1
Maryam
Fatemi
100319475328460011515
100319475328460011515
No
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University. Shiraz, Iran.
Tahoora
Shomali
tshomali@shirazu.ac.ir
100319475328460011516
100319475328460011516
Yes
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University. Shiraz, Iran.
Saeed
Nazifi
100319475328460011517
100319475328460011517
No
Department of Clinical Studies, School of Veterinary Medicine, Shiraz University. Shiraz, Iran.
Mehdi
Fazeli
100319475328460011518
100319475328460011518
No
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University. Shiraz, Iran.