en عمومى General پژوهشي Research <div style="text-align: justify;"><span style="color:#000080;"><strong>Background</strong></span>: Anti-plasmodial activities of the methanol stem bark extracts of Nauclea latifolia, and Terminalia glaucescens were investigated in mice infected with Plasmodium berghei.<br> <span style="color:#000080;"><strong>Methods</strong></span>: A total of 24 Plasmodium berghei infected (P. berghei infected) mice were divided into 8 groups of 3 each. Groups A-F were given 100, 300 or 500 mg/kg of either extracts. Groups G and H received 2 mL normal saline (negative control) and 5 mg/kg of chloroquine (positive control), respectively. The drugs and extracts were administered orally once daily for five days.&nbsp;<br> <span style="color:#000080;"><strong>Results</strong></span>: Alkaloids and flavonoids were the most and abundant metabolites in the extracts, respectively. The extract of Nauclea latifolia (N. latifolia) and Terminalia glaucescens (T. glauscecens) had Median Lethal Dose LD50 of >5000 mg/kg and 3808 mg/kg, respectively. In vivo anti-plasmodial studies revealed that the highest suppression (66.79% and 65.37%) and mean survival days (27.67&plusmn;1.45 and 30.33&plusmn;0.33) were recorded for the groups treated with 500 mg/kg N. latifolia or T. glaucescens, respectively. The infected but untreated groups survived only for 9.33&plusmn;0.88 days while chloroquine treated groups lived for 31.33&plusmn;0.88 days. The body weight and Packed Cell Volume (PCV) of rats treated with 500 mg/kg. N. latifolia or T. glaucescens significantly increased (P<0.05) compared to those in the infected but untreated groups. There was a significant loss (P<0.05) in body weight and PCV of the mice treated with 100 mg/kg of T. glaucescens compared to those in other treated groups.<br> <span style="color:#000080;"><strong>Conclusion</strong></span>: The extracts exhibited anti-plasmodial activities in mice, therefore, they may be considered potential candidates for new anti-malarial agents.</div> Acute toxicity, Anti-plasmodial, Nauclea latifolia, Phytochemicals, Terminalia glaucescens Phytochemicals, Toxicity, Anti-malarial drugs, Nauclea latifolia, Terminalia glaucescens 9 18 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-613-1&slc_lang=en&sid=1 Eustace Bonghan Berinyuy eusbong1@gmail.com 10031947532846008703 10031947532846008703 Yes Department of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon. Mann Abdullahi 10031947532846008704 10031947532846008704 No Department of Chemistry, School of Life Sciences, Federal University of Technology, Minna, Nigeria. Adamu Yusuf Kabiru 10031947532846008705 10031947532846008705 No Department of Biochemistry, School of Life Sciences, Federal University of Technology, Minna, Nigeria. Emmanuel Olofu Ogbadoyi 10031947532846008706 10031947532846008706 No Department of Biochemistry, School of Life Sciences, Federal University of Technology, Minna, Nigeria.