en عمومى General پژوهشي Research <div style="text-align: justify;"><span style="color:#000080;"><strong>Background</strong></span>: Cadmium is known as a unique heavy metal compared to others, due to its long half-life, low discharge from the body, toxicity at low concentrations and accumulation in tissues.<br> <span style="color:#000080;"><strong>Methods</strong></span>: The effects of chronic and acute Cadmium (Cd) exposure were investigated on the morphology and histopathology of 24 field rats (Millardia meltada). The rats were divided into two groups of 12 each, then sub-divided into: one control and two treatment sub-groups with Cd in the feed or water. The treatment subgroups received either 15mg/kg (low) or 30mg/kg (high) Cd concentration in the feed.&nbsp;<br> <span style="color:#000080;"><strong>Results</strong></span>: Hemorrhagic spots and fibrosis were observed in the liver of Cd treated rats compared to the controls. Also, necrosis, dilation, and calcinosis occurred in the renal tubules of the treatment groups compared to the controls. The levels of hemoglobin, red and white blood cells, hematocrit, and mean corpuscular hemoglobin were reduced, while mean corpuscular volume and hemoglobin concentrations were increased.<br> <span style="color:#000080;"><strong>Conclusion</strong></span>: This study reports the morphological, pathological and hematological abnormalities in the blood, liver and kidneys of rats due to Cd toxicity, which may be considered as the biomarkers of cadmium toxicity in other experimental mammals.</div> Cadmium, Biomarker, Hematology, Histopathology, Millardia meltada, Rats Cadmium, Biomarkers, Hematology, Histopathology, Millardia meltada, Rats 33 42 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-616-1&slc_lang=en&sid=1 Javeria Wakeel Javeriawakeel1@gmail.com 10031947532846008719 10031947532846008719 No Department of Zoology, Faculty of Wildlife and Fisheries, University of Agriculture, Faisalabad, Pakistan. Nazia Ehsan naziaeuaf@gmail.com 10031947532846008720 10031947532846008720 No Department of Zoology, Faculty of Wildlife and Fisheries, University of Agriculture, Faisalabad, Pakistan. Rana Waseem Akhtar 1251277742@qq.com 10031947532846008721 10031947532846008721 No Department of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan. Syed Aftab Hussain Shah saftabhshah@gmail.com 10031947532846008722 10031947532846008722 Yes Pakistan Scientific & Technological Information Centre, Quaid-i-Azam University Campus, Islamabad, Pakistan.