en عمومى General پژوهشي Research <div> <div style="text-align: justify;"><strong>Background</strong>: Newbouldia laevis and Crateva adansonii are popular plants used traditionally in the management of patients with malaria infection in Nigeria. In this study, the acute toxicity and anti-plasmodial effects of the leaf extracts of Newbouldia laevis and Crateva adansonii were investigated in mice.<br> <strong>Methods</strong>: The Anti-plasmodial activities of both extracts were investigated individually and combined in mice infected with the chloroquine sensitive ANKA-65 Plasmodium berghei strain. Five groups of four mice each were used in our experiments. The LD50 was determined, using the line equation of the mortality against dose levels plot.&nbsp;<br> <strong>Results</strong>: The extracts of N. laevis and C. adansonii had a safety level of 200 mg/kg (LD50= 471.43 mg/kg) and 600 mg/kg (LD50=3,500 mg/kg), respectively. Each experimental group was infected with P. berghei strain. The percent inhibition of parasitemia induced by the extracts of N. laevis and C. adansonii were 30.14&plusmn;2.88% and 61.35&plusmn;1.41%, respectively, compared to the 78.89% achieved for the standard drug (chloroquine). Mice treated with the combined extracts had a parasite inhibition of 24.23&plusmn;0.86%. Upon the analysis of the extracts, there were tannins, steroids, flavonoids, saponins and alkaloids in both. The quantitative analyses revealed that tannins were the most abundant (261.85&plusmn;4.76 mg/100 g & 92.71&plusmn;6.58 mg/100 g) while saponins were the least abundant (15.09&plusmn;1.13 mg/100 g & 14.08&plusmn;1.28 mg/100 g) phytochemicals in both extracts. &nbsp;<br> <strong>Conclusion</strong>: The findings support the notion that the traditional use of either plant in the management of malaria in Nigeria appears to be logical.<br> &nbsp;</div> </div> <address dir="rtl" style="margin-right: 80px;"></address> Toxicity, Phytochemicals, Malaria, Plasmodium berghei, Crateva adansonii, Newbouldia laevis. Toxicity, Plasmodium berghei infection, Crateva adansonii, Newbouldia laevis, Leaf extracts 93 104 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-636-1&slc_lang=en&sid=1 Amos Ndarubu Tsado infoamosandarubu@gmail.com 10031947532846009174 10031947532846009174 No Department of Basic and Applied Sciences, Niger State Polytechnic P.M.B. 01, Zungeru, Nigeria.; Department of Biochemistry, School of Life Sciences, Federal University of Technology, P.M.B. 65, Minna, Niger State, Nigeria. Audu Ali Jigam aajigam@gmail.com 10031947532846009175 10031947532846009175 No Department of Biochemistry, School of Life Sciences, Federal University of Technology, P.M.B. 65, Minna, Niger State, Nigeria. Helmina Olufunmilola Akanya funmiakanya@yahoo.com 10031947532846009176 10031947532846009176 No Department of Biochemistry, School of Life Sciences, Federal University of Technology, P.M.B. 65, Minna, Niger State, Nigeria. Ifeanyi Famous Ossamulu ossafame@gmail.com 10031947532846009177 10031947532846009177 No Department of Biochemistry, School of Life Sciences, Federal University of Technology, P.M.B. 65, Minna, Niger State, Nigeria. Stephen Damola Ariyeloye ariyeloye@gmail.com 10031947532846009178 10031947532846009178 Yes Department of Biochemistry, Institute of Health Sciences, Anadolu University, Eskisehir, Turkey.