Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1399
7
1
gregorian
2020
10
1
14
4
online
1
fulltext
en
The Toxicity Evaluation of Salvia rhytidea and Glycine Max Extracts versus the Biochemical and Histological Indices of Liver and Kidney Functions in Mice
عمومى
General
پژوهشي
Research
<div style="text-align: justify;"><strong>Background:</strong> The safety of the use of medicinal plants is a general challenge among consumers. To improve the use, it is necessary to provide complete profiles of the natural medications for quality control and the therapeutic and toxicity effects. This study was conducted to evaluate the structural and functional toxicity of the methanolic extracts of Salvia <em>rhytidea </em>and<em> Glycine</em> max plants in mice. <br>
<strong>Methods: </strong>After determining the LD<sub>50</sub>, NMRI mice with mean weight of 25-30 g were treated intraperitoneally with 100, 200 and 400 mg/kg, and orally with 800 mg/kg of the extracts for 7 consecutive days. After the last treatment, the serum samples were prepared and used for the biochemical assays. The liver and left kidney were removed from the animals and fixed in 10% formalin for histopathological examinations. <br>
<strong>Results:</strong> The results indicated that the biochemical parameters of liver and kidneys were not significantly different among the experimental and control groups (P>0.05). Mild degenerative changes in the liver and kidneys were observed at the IP dose of 400 mg/kg and oral dose of 800 mg/kg of both extracts. <br>
<strong>Conclusion:</strong> The use of these plants’ extracts did not induce severe toxicity in the short-term; however, caution should be exercised with the long-term use. </div>
Salvia rhytidea,Glycine max,Hepatotoxicity, Nephrotoxicity, Histopathological study
Salvia rhytidea, Glycine max, Hepatotoxicity, Nephrotoxicity, Histopathological study
221
228
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-642-1&slc_lang=en&sid=1
Ali
Mandegary
10031947532846009855
10031947532846009855
No
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Reza
Kheirandish
10031947532846009856
10031947532846009856
No
School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
Sepideh
Heidari
10031947532846009857
10031947532846009857
No
Herbal and Traditional Medicine Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Mansour
Mirtadzadini
10031947532846009858
10031947532846009858
No
Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
Amir
Asadi
10031947532846009859
10031947532846009859
No
Herbal and Traditional Medicine Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Navid
Hassanabadi
10031947532846009860
10031947532846009860
No
School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
Fariba
Sharififar
fa.sharififar@gmail.com
10031947532846009861
10031947532846009861
Yes
Herbal and Traditional Medicine Research Center, Kerman University of Medical Sciences, Kerman, Iran.