Iranian Journal of Toxicology
مجله سم شناسی و مسمومیتهای ایران
IJT
Medical Sciences
http://ijt.arakmu.ac.ir
1
admin
2008-2967
2251-9459
8
10.61186/ijt
14
8888
13
en
jalali
1399
10
1
gregorian
2021
1
1
15
1
online
1
fulltext
en
Toxicity and Antiparasitic Efficacy of Essential Oils: Analyses of the Biochemical Compositions and Potencies
تخصصي
Special
پژوهشي
Research
<div style="text-align: justify;"><strong>Background</strong>: Hydatidosis is a common disease of both humans and animals, resulting from infection with the larvae of Echinococcus granulosus tapeworm. The aim of this study was to investigate the antiparasitic (protoscolicidal) activities of three essential oils in vitro.<br>
<strong>Methods</strong>: This study was designed to evaluate the biochemical composition and in vitro antiparasitic effects of Zataria multiflora, Origanum vulgare and Mentha pulegium essential oils. Gas chromatography was performed to identify the main components of the herbal oils. To determine the antiparasitic properties of the essential oils, live protoscoleces from hydatid cysts were exposed to three concentrations of the herbal oils and were incubated at 37°C for 5, 10, 15, 20 or 25 minutes. <br>
<strong>Results</strong>: The biochemical analysis of these oils indicated that carvacrol and thymol were the major compounds of the Zataria oil. Further, carvacrol and thymol in Origanum essential oil and pulegone and piperitone in Mentha oil were the major compounds. The quickest and slowest antiparasitic effect was achieved from Zataria and Origanum (10%) or from Zataria (0.6%), respectively. The statistical analysis showed a significant difference between the mortality rate of protoscoleces exposed to 0.6% and 1% concentrations, respectively, of Zataria and Origanum at the predetermined exposure times (P<0.05). The three concentrations of Mentha had the same significant statistical differences (P<0.05).<br>
<strong>Conclusion</strong>: Essential oils, Zataria multiflora, Origanum vulgare and Mentha pulegium had significant protoscolicidal activities that were dependent on the concentration of the oils and the exposure times.<br>
</div>
<h1></h1>
Protoscoleces, Zataria multiflora, Origanum vulgare, Mentha pulegium, Micro-emulsion, Macro-emulsion
Protoscoleces, Essential oils, Zataria multiflora, Origanum vulgare, Mentha pulegium
1
8
http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-727-1&slc_lang=en&sid=1
Emad
Soleimani
عماد
سلیمانی
100319475328460010381
100319475328460010381
No
Student Research Committee, Arak University of Medical Sciences, Arak, Iran.
Hossein
Sarmadian
حسین
سرمدیان
100319475328460010382
100319475328460010382
No
Department of Infectious Disease, School of Medicine, Arak University of Medical Sciences. Arak, Iran.
Mohammad
Arjomand Zadegan
محمد
ارجمندزادگان
100319475328460010383
100319475328460010383
No
Department of Microbiology, Infectious Diseases Research Center (IDRC), School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Reza
Ghasemikhah
رضا
قاسمی خواه
ghasemikhah@yahoo.com
100319475328460010384
100319475328460010384
Yes
Department of Pediatrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Hasan
Taher Ahmadi
حسن
طاهر احمدی
100319475328460010385
100319475328460010385
No
Department of Parasitology and Mycology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.