en تخصصي Special پژوهشي Research <strong>Background</strong>: Excitotoxicity is a common pathological process in neurodegenerative diseases associated with overactivity of N-methyl-D-aspartate (NMDA) and P/Q type voltage-gated calcium (Cav2.1) channels. Omega-lycotoxin-Gsp2671g&nbsp;is a therapeutic tool to modulate overactive Cav2.1 (P/Q type) channels. Omega-lycotoxin binds to Cav2.1 channels with high affinity and selectivity. This study aimed to investigate the effects of Omega-lycotoxin on the cognitive impairment induced by kainic acid in rats.<br> <strong>Methods</strong>: The effect of pre-treatment and post-treatment trials of intra-hippocampal Cornu Ammonis-3 administration of omega-lycotoxin (0.5, 1 or 2&micro;g) was studied on the cognitive impairment induced by kainic acid in rats. The rats&rsquo; learning and memory were assessed by the passive avoidance and a single-day testing version of the Morris water maze method.<br> <strong>Results</strong>: Omega-lycotoxin caused a significant increase in the latency of the passive avoidance test and the duration of their presence in the target area of the Morris water maze test compared to the groups treated with kainic acid (P<0.0001). There were statistically significant differences for the effects of various doses of omega-lycotoxin. The post-treatment groups showed a greater improvement than those in the pretreatment groups.<br> <strong>Conclusion</strong>: The findings demonstrated that a single dose of omega-lycotoxin can prevent or revert the memory impairment caused by kainic acid in rats. &nbsp; Calcium Channel Blockers, Kainic acid, Memory, calcium channel, Rats Calcium channel blockers, Kainic acid, Memory &, avoidance tests, Calcium channel Cav2.1 (P/Q type) 49 56 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-740-1&slc_lang=en&sid=1 Ali Hosseini-Sharifabad علی حسینی شریف آباد hosseini_a@pharm.mui.ac.ir 100319475328460010404 100319475328460010404 No Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. دانشکده داروسازی اصفهان، گروه فارماکولوژی و سم شناسی Mohammad Reza Mofid محمدرضا مفید mofid@pharm.mui.ac.ir 100319475328460010405 100319475328460010405 No Department of Clinical Biochemistry, Bioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. دانشکده داروسازی اصفهان، گروه بیوشیمی بالینی Majid Moradmand مجید مرادمند moradmand.arachnids@gmail.com 100319475328460010406 100319475328460010406 No Department of Animal and Plant Biology, Faculty of Biological Sciences and Technology, University of Isfahan, Isfahan, Iran. دانشکده علوم های زیستی و تکنولوژی، گروه جانوری و گیاهی Mohammad Keimasi محمد کیماسی keimasimohammed@gmail.com 100319475328460010407 100319475328460010407 Yes Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. دانشکده داروسازی اصفهان، گروه فارماکولوژی و سم شناسی