en عمومى General پژوهشي Research <div style="text-align: justify;"><strong>Background</strong>: Chemotherapy agents can cause ovarian dysfunction and eventually lead to infertility. This study investigated the effect of nasturtium officinale extract on the ovarian function following the toxicity induced by doxorubicin in female rats.<br> <strong>Methods</strong>: Forty eight female Wistar rats (180-210g) were randomly divided in six groups as follows: Group I, normal rats receiving 1ml normal saline; Group II and III receiving 25 and 75 mg/kg of the extract daily by gavage for 21 days. Groups IV, V and VI receiving 10 mg/kg doxorubicin intraperitoneally on the first day. In addition, Group IV and V received 25 and 75 mg/kg of the extract, respectively. The serum levels of estrogen, progesterone, Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and ovarian Malondialdehyde (MDA) were determined after 21 days of treatment. The mean numbers of various graafian follicles and corpus lutea were recorded after treatment.<br> <strong>Results</strong>: The mean serum FSH level in Group VI (0.11&plusmn;0.01) significantly reduced compared to those in Groups II (0.21&plusmn;0.05) and III (0.23&plusmn;0.01), (P<0.05). The mean serum LH and estrogen levels in Group VI (0.16&plusmn;0.08) reduced insignificantly compared to those in the controls (0.21&plusmn;0.02), and in Groups II (0.23&plusmn;0.03) and III (0.22&plusmn;0.09). A significant reduction in the number of primary, secondary and graafian follicles were observed in Group VI compared to the control group (P<0.05). The serum MDA level significantly declined in Group V compared to that in Group VI (P<0.05).<br> <strong>Conclusion</strong>: The nasturtium officinale extract attenuated the toxic effect of doxorubicin on the rat ovaries and protected the cell division in the follicles and the oocytes maturation.<br> <br> <div></div></div> Doxorubicin, Drug Interactions, Nasturtium officinale, Ovary, Rats Doxorubicin, Drug interactions, Nasturtium officinale, Ovaries, Rats​​​​​​​ 57 64 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-747-1&slc_lang=en&sid=1 Parastou Rad پرستو راد parastou.rad@gmail.com 100319475328460010408 100319475328460010408 No Department of Nursing, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran. دانشگاه علوم پزشکی یاسوج Fahimeh Safari فهیمه صفری fahima_jefri33@yahoo.com 100319475328460010409 100319475328460010409 No Department of Biology, Cellular and Molecular Research Center, Shiraz University, Shiraz, Iran. دانشگاه ازاد اسلامی شیراز Jamshid Mohammadi جمشید محمدی j.mohammadi.4554@gmail.com 100319475328460010410 100319475328460010410 No Department of Physiology, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran. دانشگاه علوم پزشکی یاسوج، دانشکده پزشکی، گروه فیزیولوزی Hamdollah Delaviz حمداله دلاویز delavizhamdi83@gmail.com 100319475328460010411 100319475328460010411 Yes Cellular and Molecular Research Center, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran. مرکز تحقیقات سلولی و مولکولی