en Acute Liver Dysfunction Associated With Interferon-Beta-1a (Avonex®) Use in A Young Female Patient with Relapsing-Remitting Multiple Sclerosis (RRMS) عمومى General پژوهشي Research <span style="font-weight: bold">Background:</span> It has been reported that liver function alterations occur in 8–38% of patients with relapsing-remitting multiple sclerosis (RRMS) treated with interferon-beta in controlled clinical trials or in prospective but non-controlled studies. We report herein a case of symptomatic liver dysfunction associated with two-year-period of regular interferon-beta-1a (Avonex®) intramuscular injections in a young female patient with relapsing-remitting multiple sclerosis. <br><span style="font-weight: bold">Case:</span> The patient was 19 year-old female with clinically proved RRMS, treated with interferon-beta-1a (Avonex®) 30 µg weekly by intramuscular injections for two years. She was referred with clinical symptoms of liver dysfunction including abdominal peri-umbilical and right upper quadrant pain, anorexia and malaise, that constipation, dark urine and icterus. Laboratory studies corroborated acute hepatitis state without any viral, autoimmune or drug-related causes. Patient's status improved after two weeks of conservative therapy and withholding interferon. Billirubin, liver function tests and liver enzyme values returned to normal. <br><span style="font-weight: bold">Conclusion:</span> Interferon-beta compounds could have serious hepatic complications, and patients using interferon-beta-1a should regularly monitor their liver function. Interferon-Beta-1a, Avonex®, Relapsing-Remitting Multiple Sclerosis (RRMS), Acute Liver Dysfunction Interferon-Beta-1a, Avonex®, Relapsing-Remitting Multiple Sclerosis (RRMS), Acute Liver Dysfunction 8 8 http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-2-66&slc_lang=en&sid=1 Ali Reza Rezaei Ashtiani علیرضا رضایی آشتیانی r110_ashtiani@yahoo.com 10031947532846003477 10031947532846003477 Yes Department of Neurology, Vali-E-Asr. Medical Center,Arak Medical university, Arak, Iran Department of Neurology, Vali-E-Asr. Medical Center,Arak Medical university, Arak, Iran Babak Zamani بابک زمانی 10031947532846003478 10031947532846003478 No Department of Neurology,Rasol-e-Akram Medical Center, Tehran, Iran Department of Neurology,Rasol-e-Akram Medical Center, Tehran, Iran Mohammad Rohani محمد روحانی 10031947532846003479 10031947532846003479 No Department of Neurology,Rasol-e-Akram Medical Center, Tehran, Iran Department of Neurology,Rasol-e-Akram Medical Center, Tehran, Iran