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Volume 12, Issue 5 (September-October 2018)
IJT 2018, 12(5): 23-26 |
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Majidi M, Delirrad M, Banagozar Mohammadi A, Najaf Najafi M, Nekoueifard S, Alizadeh A et al . Cholinesterase Level in Erythrocyte or Serum: Which is More Predictive of the Clinical Outcome in Patients with Acute Organophosphate Poisoning?. IJT 2018; 12 (5) :23-26
URL: http://ijt.arakmu.ac.ir/article-1-697-en.html
URL: http://ijt.arakmu.ac.ir/article-1-697-en.html
Mohammad Majidi1 
, Mohammad Delirrad *2 , Ali Banagozar Mohammadi3 , Mona Najaf Najafi4 , Solmaz Nekoueifard5 , Anahita Alizadeh6 , Bita Dadpour6
, Mohammad Delirrad *2 , Ali Banagozar Mohammadi3 , Mona Najaf Najafi4 , Solmaz Nekoueifard5 , Anahita Alizadeh6 , Bita Dadpour6
1- Department of Forensic Medicine and Clinical Toxicology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
2- Department of Forensic Medicine and Clinical Toxicology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. ,delirrad@umsu.ac.ir
3- Department of Internal Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
4- Department of Clinical Research, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5- MD, Urmia Health Center, Urmia, Iran.
6- Department of Clinical Toxicology, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
2- Department of Forensic Medicine and Clinical Toxicology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. ,
3- Department of Internal Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
4- Department of Clinical Research, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5- MD, Urmia Health Center, Urmia, Iran.
6- Department of Clinical Toxicology, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
Abstract: (3906 Views)
Background: Acute organophosphate poisoning (AOPP) is related to several clinical complications that may be fatal. The aim of this study was to evaluate the effects of demographic, clinical and laboratory findings on AOPP outcome.
Methods: In this retrospective cross-sectional study, medical records of all patients with AOPP admitted to Imam Reza Hospital, Mashhad, Iran, were reviewed from January 2016 to December 2017. Demographic data, clinical presentations, erythrocyte cholinesterase (RBC-ChE) and serum cholinesterase (S-ChE) activities were studied and evaluated in relation to clinical outcome of the patients.
Results: A total of 64 patients (37 male, 27 female) were evaluated from whom 6 patients (9.4%) died. Statistically significant relationships were found between the outcome of the patients and RBC-ChE activity (p =0.008), intratracheal intubation (p=0.003), and abnormal blood pressure (p =0.009). Despite the lower mean S-ChE levels in the deceased patients and loss of consciousness in 42.2% (n=27) of patients, there was no statistically significant correlations between these factors and patients’ outcome (p =0.147, p =0.075, respectively).
Conclusion: RBC-ChE activity, need for intratracheal intubation, and abnormal blood pressure on admission were important predictive factors in the clinical outcome of AOPP. Although S-ChE activity, level of consciousness, white blood cell count and blood glucose level on admission provide useful information, these data had no prognostic value in patients with AOPP.
Methods: In this retrospective cross-sectional study, medical records of all patients with AOPP admitted to Imam Reza Hospital, Mashhad, Iran, were reviewed from January 2016 to December 2017. Demographic data, clinical presentations, erythrocyte cholinesterase (RBC-ChE) and serum cholinesterase (S-ChE) activities were studied and evaluated in relation to clinical outcome of the patients.
Results: A total of 64 patients (37 male, 27 female) were evaluated from whom 6 patients (9.4%) died. Statistically significant relationships were found between the outcome of the patients and RBC-ChE activity (p =0.008), intratracheal intubation (p=0.003), and abnormal blood pressure (p =0.009). Despite the lower mean S-ChE levels in the deceased patients and loss of consciousness in 42.2% (n=27) of patients, there was no statistically significant correlations between these factors and patients’ outcome (p =0.147, p =0.075, respectively).
Conclusion: RBC-ChE activity, need for intratracheal intubation, and abnormal blood pressure on admission were important predictive factors in the clinical outcome of AOPP. Although S-ChE activity, level of consciousness, white blood cell count and blood glucose level on admission provide useful information, these data had no prognostic value in patients with AOPP.
Keywords: Acetyl Cholinesterase, Organophosphate Poisoning, Patient Outcome Assessment, Serum Cholinesterase
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
