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Volume 1, Issue 2 (Summer 2007)
IJT 2007, 1(2): 4-4 |
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Moalem M, Ghorbani A, Adel Moalem S, Balali M, Solhi H. Determining Rest Concentration of Diazinon in Agriculture Products (Melon And Cucmber) with GC-NPD and GC-MS Methods. IJT 2007; 1 (2) :4-4
URL: http://ijt.arakmu.ac.ir/article-1-29-en.html
URL: http://ijt.arakmu.ac.ir/article-1-29-en.html
1- MSc of Toxicology
2- Department of Toxicology, Ahvaz Medical University, Ahvaz,Iran
3- Department of Toxicology, Mashhad Medical University, Mashhad, Iran
4- Department of Toxicology, Arak Medical University, Arak, Iran ,solhi2@yahoo.com
2- Department of Toxicology, Ahvaz Medical University, Ahvaz,Iran
3- Department of Toxicology, Mashhad Medical University, Mashhad, Iran
4- Department of Toxicology, Arak Medical University, Arak, Iran ,
Abstract: (11050 Views)
Introduction: Diazinon is a moderately toxic broad-spectrum organophosphate, with a LD50 of 350 to 400 mg/kg for humans. Diazinon is absorbed through the skin and gastrointestinal tract and is rapidly metabolized within a few hours. Diazinon residues in melons and cucumbers have recently became a major health concern in Iran. Thus we decided to investigate Diazinon levels in melon and cucumbers.
Method and Materials: Twenty cucumbers and 30 melons were randomly purchased from the market in Mashhad. The extraction procedure was in HR-P columns precondition with methanol and water. The subsequent elution of diazinon was accomplished by a mixture of hexane-ethyl acetate (1:1, v/v) prior to determination by GC-NPD and GC-MS/MS. Standards were prepared spiking blank juice samples to contract the observed matrix effect.
Results: Mean recovery rate for diazinon was 95.4% with relative standard deviation lower than %9 in a concentration range of 5-200ng/ml. Mean and SD of diazinon in melons was 107.64±38.5 ng/kg. Diazinon was not detected in cucumber samples. It was later confirmed that diazinon was not used for the crops of these cucumbers.
Conclutions: GC-NPD and MS/MS was developed to determine residues of diazinon in melons and cucumbers. The GC-MS/MS analytical method showed a high efficacy for determination of dizinon residues in the fruits.
Results: Mean recovery rate for diazinon was 95.4% with relative standard deviation lower than %9 in a concentration range of 5-200ng/ml. Mean and SD of diazinon in melons was 107.64±38.5 ng/kg. Diazinon was not detected in cucumber samples. It was later confirmed that diazinon was not used for the crops of these cucumbers.
Conclutions: GC-NPD and MS/MS was developed to determine residues of diazinon in melons and cucumbers. The GC-MS/MS analytical method showed a high efficacy for determination of dizinon residues in the fruits.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
