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Volume 2, Issue 3 (Autumn 2009)
IJT 2009, 2(3): 221-227 |
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Soltaninejad K, Shadnia S, Hasaninejad F, Jabbari F, Abdollahi M. Evaluation of Anticonvulsant Effects of Nimodipine and Ascorbic Acid on Pentylenetetrazole- Induced Seizures in Mice. IJT 2009; 2 (3) :221-227
URL: http://ijt.arakmu.ac.ir/article-1-72-en.html
URL: http://ijt.arakmu.ac.ir/article-1-72-en.html
Kambiz Soltaninejad * 
1, Shahin Shadnia2 , Fatemeh Hasaninejad3 , Friba Jabbari3 , Mohammad Abdollahi4
1, Shahin Shadnia2 , Fatemeh Hasaninejad3 , Friba Jabbari3 , Mohammad Abdollahi4
1- Department of Forensic Toxicology, Legal Medicine Organization of Iran, Tehran, Iran , kamsoltani@yahoo.com
2- Loghman-Hakim Hospital Poison Center and Toxicology Resaerch Center,Faculty of Medicine, Shahid Beheshit Medical Sciences University, Tehran, Iran
3- Department of Toxicology, and Pharmacology,Faculty of Pharmacy, Islamic Azad University, Tehran, Iran
4- Department of Toxicology, and Pharmacology,Faculty of Pharmacy; and Pharmaceutical Sciences Research Center.Tehran Medical Sciences University, Tehran, Iran
2- Loghman-Hakim Hospital Poison Center and Toxicology Resaerch Center,Faculty of Medicine, Shahid Beheshit Medical Sciences University, Tehran, Iran
3- Department of Toxicology, and Pharmacology,Faculty of Pharmacy, Islamic Azad University, Tehran, Iran
4- Department of Toxicology, and Pharmacology,Faculty of Pharmacy; and Pharmaceutical Sciences Research Center.Tehran Medical Sciences University, Tehran, Iran
Abstract: (7811 Views)
Introduction: The mechanisms underlying the vulnerability of the brain to seizures remains unknown. Calcium ions influx and oxidative stress have been implicated in a variety of acute and chronic epileptogenic conditions. The present study was aimed at investigating the effects of nimodipine and ascorbic acid (vitamin C) alone and in combination on pentylenetetrazole (PTZ) - induced seizures in mice.
Material and methods: The animals received nimodipine (0.5, 1, 1.5, 2 mg/Kg, i.p.), ascorbic acid (30, 100, 300 mg/Kg, i.p.) alone and in combination with sodium valproate (100 mg/Kg, i.p.), 15 and 30min prior to intra-peritonral injection of PTZ (60 mg/Kg) and the acute seizure parameters such as seizure latency, duration and protection percent were studied in each group.
Results: Ascorbic acid alone did not have any effects on the seizure parameters and the number of mice convulsing ( P>0.05). Nimodipine in 2 mg/kg dose had full protective effect on PTZ- induced seizure parameters, and in lesser doses it exerted partial protective effects. The combination of ascorbic acid (300 mg/Kg) with nimodipine (1.5 mg/Kg) or sodium valproate had a significant synergistic protective effect against PTZ- induce seizures in comparison with controls( P<0.001).
Conclusion: Ascorbic acid potentiates the anticonvulsive effects of nimodipine on PTZ-induced seizure in mice.
Material and methods: The animals received nimodipine (0.5, 1, 1.5, 2 mg/Kg, i.p.), ascorbic acid (30, 100, 300 mg/Kg, i.p.) alone and in combination with sodium valproate (100 mg/Kg, i.p.), 15 and 30min prior to intra-peritonral injection of PTZ (60 mg/Kg) and the acute seizure parameters such as seizure latency, duration and protection percent were studied in each group.
Results: Ascorbic acid alone did not have any effects on the seizure parameters and the number of mice convulsing ( P>0.05). Nimodipine in 2 mg/kg dose had full protective effect on PTZ- induced seizure parameters, and in lesser doses it exerted partial protective effects. The combination of ascorbic acid (300 mg/Kg) with nimodipine (1.5 mg/Kg) or sodium valproate had a significant synergistic protective effect against PTZ- induce seizures in comparison with controls( P<0.001).
Conclusion: Ascorbic acid potentiates the anticonvulsive effects of nimodipine on PTZ-induced seizure in mice.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
