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Volume 14, Issue 3 (July 2020)
IJT 2020, 14(3): 155-164 |
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Khoshnoud M J, Keshavarzi M, Mokhtari N, Sakhteman A, Derakhshanfar A, Rashedinia M. The Protective Effect of Nortriptyline Against Gastric Lesions Induced by Indomethacin and Cold-shock Stress in Rats. IJT 2020; 14 (3) :155-164
URL: http://ijt.arakmu.ac.ir/article-1-809-en.html
URL: http://ijt.arakmu.ac.ir/article-1-809-en.html
Mohammad Javad Khoshnoud1 
, Majid Keshavarzi2 , Neda Mokhtari3 , Amirhossein Sakhteman4 , Amin Derakhshanfar5 , Marzieh Rashedinia * 6
, Majid Keshavarzi2 , Neda Mokhtari3 , Amirhossein Sakhteman4 , Amin Derakhshanfar5 , Marzieh Rashedinia * 6
1- Food and Supplements Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences. Shiraz, Iran.
3- Department of Pharmacology Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
5- Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
6- Department of Pharmacology Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. , rashedinia@sums.ac.ir
2- Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences. Shiraz, Iran.
3- Department of Pharmacology Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
4- Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
5- Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
6- Department of Pharmacology Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. , rashedinia@sums.ac.ir
Abstract: (2201 Views)
Background: Gastric ulcer is among the most serious stomach disorder universally. Several effective drugs are employed in the management of this disease, although there have been adverse effects in some cases. The aim of this study was to investigate the effect of nortriptyline to protect against gastric lesions, induced by indomethacin or cold-stress in rats.
Methods: Gastric lesions were induced by oral indomethacin (30 mg/kg) or cold-shock at 2-4°C. Animals were pre-treated with 5, 10 or 20 mg/kg nortriptyline. After 4hr of exposure to indomethacin or cold shock, the stomach was removed for histological examinations and the levels of enzymatic and non-enzymatic oxidative stress markers were determined in the tissue samples.
Results: The results showed that nortriptyline at 20 mg/kg significantly restored the activity of the oxidative stress markers, such as Superoxide Dismutase (SOD) and Catalase (CAT) enzymes. It also decreased the tissue Malondialdehyde (MDA) concentration. In addition, nortriptyline at 20 mg/kg, ameliorated the gastric tissue damages caused by indomethacin or the cold shock.
Conclusion: The results suggest that improvement in gastric mucosal lesions can be mediated by nortriptyline pretreatment, which is likely due to its antioxidant property.
Methods: Gastric lesions were induced by oral indomethacin (30 mg/kg) or cold-shock at 2-4°C. Animals were pre-treated with 5, 10 or 20 mg/kg nortriptyline. After 4hr of exposure to indomethacin or cold shock, the stomach was removed for histological examinations and the levels of enzymatic and non-enzymatic oxidative stress markers were determined in the tissue samples.
Results: The results showed that nortriptyline at 20 mg/kg significantly restored the activity of the oxidative stress markers, such as Superoxide Dismutase (SOD) and Catalase (CAT) enzymes. It also decreased the tissue Malondialdehyde (MDA) concentration. In addition, nortriptyline at 20 mg/kg, ameliorated the gastric tissue damages caused by indomethacin or the cold shock.
Conclusion: The results suggest that improvement in gastric mucosal lesions can be mediated by nortriptyline pretreatment, which is likely due to its antioxidant property.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
