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Abd El-Wahaab A. Dawood, Manal M Shehata, Randa H Abdel-Hady, Khaled M Abdel-Aal, Heba A Yassa,
Volume 2, Issue 4 (Winter 2009)
Abstract

Background: The present study was designed to determine the risk factors that lead to bango abuse among secondary school student and drivers in Assiut province.
Subjects and Method: urine samples were taken from 1000 volunteers after filling a questionnaire, 500 students from different secondary schools and 500 drivers in Assiut province. The risk factors that lead to bango abuse among drivers and students were determined through the questionnaire. Screenings of the samples were done by using Thin Layer Chromatography (TLC) and then positive samples confirmed by high performance liquid chromatography (HPLC).
Results: prevalence of bango abuse was 12% in drivers of the studied group. Bango abuse concentrated in age group of 21- 31Y/O by 51.7% and in those driving microbus, van and half van by 30%, 28.3% and 23.3% respectively. Abuse was more among cigarette and shisha smokers by 83.3% and 100% respectively. Also it was found that bango abuse is more prevalent in cases with 5 - 15Y work experience (58.3%of cases). In students, it was found that bango abuse was prevalent in 11.6%, concentrated in male students by 100%, and in those with daily fund more than one pound (44.8%). The abused students tend to be more aggressive toward their friends and their family members (by 65.5% and 96.6% respectively).
Conclusion: bango abuse leads to deterioration of the academic achievement, and may be associated with antisocial and violent behavior, which may be a leading cause to develop crime.
Mr Omar Hassanein, Dr Ibrahim A. El-Elaimy, Dr Mohamed F.f. Bayomy, Dr Ahmed M. Shehata, Dr Hany M. Ibrahim,
Volume 18, Issue 2 (May 2024)
Abstract

Background: Valproic acid (VPA) is a well-known antiepileptic drug; however, it has adverse effects on different body organs, particularly as a result of inducing oxidative stress in the liver. Taurine (Tau) is an amino acid prevalent in the brain that possesses anti-tumor, anti-toxic, and antioxidant properties. This study aimed to investigate the potential of the co-treatment of Tau in mitigating the deleterious effects of VPA in pentylenetetrazole (PTZ) epileptic rats.
Methods: A total of 42 rats were divided into six groups of seven as follows: control group, PTZ-treated group (single dose, 60 mg/kg intraperitoneally [IP]), VPA-treated group (500 mg/kg IP for 14 days), Tau-treated group (100 mg/kg orally for 28 days), VPA+PTZ group, and Tau+VPA+PTZ group. The liver function, antioxidant status, and lipid profile markers were evaluated spectrophotometrically.
Results: The IP injection of PTZ and VPA elevated aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and gamma-glutamyltransferase levels. These treatments caused negative alterations in protein concentrations, antioxidant status, and lipid profile markers of the rats’ sera. The treatment with Tau+VPA, on the other hand, improved liver function, restored fairly normal total protein and albumin levels, and improved malondialdehyde, glutathione peroxidase, and total antioxidant capacity concentrations. Furthermore, the Tau+VPA treatment significantly controlled total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein levels, compared to the VPA+PTZ treatment.
Conclusion: The treatment with Tau+VPA is highly effective in controlling the unfavorable side effects of VPA in an epileptic rat model.


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