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Volume 19, Issue 3 (July 2025)
IJT 2025, 19(3): 0-0 |
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Ethics code: IR.LUMS.REC.1400.153
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Ghaffarian-Bahraman A, Mohammadi S, Shahmohammadloo R, Heidari S, Mohammadi H. The Effects of taurine on Rifampin-Induced Liver Injury. IJT 2025; 19 (3)
URL: http://ijt.arakmu.ac.ir/article-1-1372-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1372-en.html
Ali Ghaffarian-Bahraman1 
, Salman Mohammadi2 , Reza Shahmohammadloo3 , Salma Heidari4 , Hamidreza Mohammadi *5
, Salman Mohammadi2 , Reza Shahmohammadloo3 , Salma Heidari4 , Hamidreza Mohammadi *5
1- Assistant Professor of Pharmacology and Toxicology, Occupational Environment Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2- Assistant Professor of Nutritional Sciences, Department of Nutrition, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Pharmacy Student; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
4- Pharmacy Student; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
5- Assistant Professor; Dept. of Toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran. ,hamidrezamohammadi65@yahoo.com
2- Assistant Professor of Nutritional Sciences, Department of Nutrition, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Pharmacy Student; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
4- Pharmacy Student; Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
5- Assistant Professor; Dept. of Toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran. ,
Abstract: (97 Views)
Background: Rifampin (RIF) is first line drugs widely used to treat tuberculosis (TB) and has been reported to be correlated with some side effects including hepatotoxicity. This study assessed the hepatoprotective potential of taurine (Tau) as an antioxidant against Rifampin-induced liver damage in rats.
Methods: Six groups of six male rats each (n = 36) were included in the present study. Rats were treated with RIF (100 mg/kg/day) or co-treated with Rif + Tau (100, 500 or 1000 mg/kg/day) for 14 days. A single Tau treatment at a dose of 1000 mg/kg/day was administered in order to investigate its hepatotoxic effects. Liver function test was used to assess Alanine transaminase (ALT), Aspartate transaminase (AST), Lactate dehydrogenase (LDH) in animals’ blood serum samples. Bilirubin was estimated along with liver levels of glutathione (GSH), reactive oxygen species (ROS), total antioxidant capacity (TAC), and lipid peroxidation (LPO).
Results: Treatment with RIF significantly increased ROS and LP in liver, and ALT, AST, LDH, and bilirubin in the sera. Also, the hepatic levels of GSH and FRAP decreased in rats treated with RIF. However, different doses of Tua significantly ameliorated the RIF-induced oxidative stress and impaired liver function.
Conclusions: The study findings indicated that Tua improved hepatotoxicity caused by RIF via inhibiting oxidative damage of the hepatic tissue in male rats.
Methods: Six groups of six male rats each (n = 36) were included in the present study. Rats were treated with RIF (100 mg/kg/day) or co-treated with Rif + Tau (100, 500 or 1000 mg/kg/day) for 14 days. A single Tau treatment at a dose of 1000 mg/kg/day was administered in order to investigate its hepatotoxic effects. Liver function test was used to assess Alanine transaminase (ALT), Aspartate transaminase (AST), Lactate dehydrogenase (LDH) in animals’ blood serum samples. Bilirubin was estimated along with liver levels of glutathione (GSH), reactive oxygen species (ROS), total antioxidant capacity (TAC), and lipid peroxidation (LPO).
Results: Treatment with RIF significantly increased ROS and LP in liver, and ALT, AST, LDH, and bilirubin in the sera. Also, the hepatic levels of GSH and FRAP decreased in rats treated with RIF. However, different doses of Tua significantly ameliorated the RIF-induced oxidative stress and impaired liver function.
Conclusions: The study findings indicated that Tua improved hepatotoxicity caused by RIF via inhibiting oxidative damage of the hepatic tissue in male rats.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
