Enter your email address
Submit
Write your message
Volume 19, Issue 2 (April 2025)
IJT 2025, 19(2): 0-0 |
Back to browse issues page
Ethics code: 240PHY2723
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Archibong A, Oyama S, Uquetan S, Etim I, Orji E, Mfem C, et al . Ameliorative effect of Periwinkle diet on lipid profile and some biochemical parameters in Phenylhydrazine-induced derangements. IJT 2025; 19 (2)
URL: http://ijt.arakmu.ac.ir/article-1-1453-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1453-en.html
Archibong Archibong *1 
, Sonnie Oyama2 , Sam Uquetan3 , Irene Etim3 , Effioanwan Orji4 , Charles Mfem3 , Daniel Owu3 , Ofem Ofem3
, Sonnie Oyama2 , Sam Uquetan3 , Irene Etim3 , Effioanwan Orji4 , Charles Mfem3 , Daniel Owu3 , Ofem Ofem3
1- Department of Human Physiology, University of Calabar, Calabar- Nigeria , Archibongarchibong21@yahoo.com
2- Department of Family Medicine, University of Alberta, Canada
3- Department of Human Physiology, University of Calabar, Calabar- Nigeria
4- College of Nursing and Midwifery Sciences, Itighidi, Cross River State-Nigeria
2- Department of Family Medicine, University of Alberta, Canada
3- Department of Human Physiology, University of Calabar, Calabar- Nigeria
4- College of Nursing and Midwifery Sciences, Itighidi, Cross River State-Nigeria
Abstract: (87 Views)
Background: Anaemia is a haematological anomaly characterized by the deficiency of Red blood cell (RBC) count, Haemoglobin content and Packed cell volume (PVC). It is a serious global health concern that particularly affects young children and pregnant women, WHO estimates that 42% of children less than 5 years of age and 40% of pregnant women worldwide are anaemic. Periwinkles are water-bodies resources of substantial economic value in the world of fisheries. They form vital source of protein and are deposited in different water bodies. seafoods are abundant sources of selenium, Vit A, Vit D, Vit E, Vit B12, Vit B6, thiamine, proteins and essential fatty acid. They have also been shown to enhance erythropoiesis.
The aim of this study is to investigate the biochemical boosting capacity of TFD (having high antioxidants, vitamins and mineral content) and other associated parameters on Wistar rats following Phenylhydrazine (PHZ)-induced hemolytic anemia and possible mechanism of action.
Methods: Twenty-four [24] male Wistar rats weighing between 180-250g were used for this study. The rats were randomly assigned into 4 groups (n = 6). Group 1: (Control) received normal feed and drinking water. Group 2: received 600 mg/kg body weight of TFD orally. Group 3: received PHZ at a dose of 40 mg/kg body weight (IP). Group 4: received same as group 2 (600 mg/kg body weight of TFD orally) plus group 3 (40mg/kg body weight of PHZ, intraperitoneally). The research lasted for forty-two (42) days, thereafter the rats were sacrificed and blood samples collected for relevant analysis.
Result: The result shows an increase (P<0.05) in Low density lipoprotein-cholesterol, Total cholesterol, Triglyceride, Cardiac risk ratio, Atherogenic coefficient, Atherogenic index in plasma, Malondialdehyde, Alanine transaminase, Alkaline phosphatase, Aspartate transaminase, Na+, Cl-, Total bilirubin, Unconjugated bilirubin, urea, uric acid and creatinine in PHZ group compare to control and TFD group but were reversed i.e. decreased (P<0.05) in PHZ+TFD group compared to PHZ group. High density lipoprotein-cholesterol, Catalase, Superoxide dismutase, Glutathione peroxidase, Total protein, Albumin, Globulin, K+, HCO3-, Fe2+, Ca2+ and CB were all decreased (P<0.05) in PHZ group compared to control and TFD but they were all increased (P<0.05) in the PHZ+TFD group compared to PHZ.
Conclusion: PHZ-induction in Wistar rats is associated with atherogenic and hepatoxic impairment. TFD diet ingestion is capable of ameliorating this condition via modulation of pro/ antioxidant activities.
The aim of this study is to investigate the biochemical boosting capacity of TFD (having high antioxidants, vitamins and mineral content) and other associated parameters on Wistar rats following Phenylhydrazine (PHZ)-induced hemolytic anemia and possible mechanism of action.
Methods: Twenty-four [24] male Wistar rats weighing between 180-250g were used for this study. The rats were randomly assigned into 4 groups (n = 6). Group 1: (Control) received normal feed and drinking water. Group 2: received 600 mg/kg body weight of TFD orally. Group 3: received PHZ at a dose of 40 mg/kg body weight (IP). Group 4: received same as group 2 (600 mg/kg body weight of TFD orally) plus group 3 (40mg/kg body weight of PHZ, intraperitoneally). The research lasted for forty-two (42) days, thereafter the rats were sacrificed and blood samples collected for relevant analysis.
Result: The result shows an increase (P<0.05) in Low density lipoprotein-cholesterol, Total cholesterol, Triglyceride, Cardiac risk ratio, Atherogenic coefficient, Atherogenic index in plasma, Malondialdehyde, Alanine transaminase, Alkaline phosphatase, Aspartate transaminase, Na+, Cl-, Total bilirubin, Unconjugated bilirubin, urea, uric acid and creatinine in PHZ group compare to control and TFD group but were reversed i.e. decreased (P<0.05) in PHZ+TFD group compared to PHZ group. High density lipoprotein-cholesterol, Catalase, Superoxide dismutase, Glutathione peroxidase, Total protein, Albumin, Globulin, K+, HCO3-, Fe2+, Ca2+ and CB were all decreased (P<0.05) in PHZ group compared to control and TFD but they were all increased (P<0.05) in the PHZ+TFD group compared to PHZ.
Conclusion: PHZ-induction in Wistar rats is associated with atherogenic and hepatoxic impairment. TFD diet ingestion is capable of ameliorating this condition via modulation of pro/ antioxidant activities.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
