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Volume 8, Issue 27 (Winter 2015)
IJT 2015, 8(27): 1216-1221 |
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Zayerzadeh E. Inhibition of Nephrotoxic Activity of Mesobuthus Eupeus Scorpion Venom by Commercial Polyvalent Antivenom in Rabbits. IJT 2015; 8 (27) :1216-1221
URL: http://ijt.arakmu.ac.ir/article-1-382-en.html
URL: http://ijt.arakmu.ac.ir/article-1-382-en.html
Department of Biology, Food Industry and Agriculture Research Center, Standard Research Institute, Karaj, Iran. , zayerzadeh@standard.ac.ir
Abstract: (5261 Views)
Background: Immunotherapy is the only specific treatment for scorpion envenomation. In the present study, the protective effects of polyvalent antivenom against histopathological complications in kidneys and marker changes (BUN and creatinine) induced by Mesobuthus eupeus (Me) scorpion venom was investigated in anesthetized rabbits.
Methods: Twenty four rabbits were randomized into four groups: six rabbits in control group were received 1 ml distilled water subcutaneously (group 1). In group 2, sublethal dose of Me venom (4 mg/kg) was injected subcutaneously. Simultaneously venom (subcutaneously 1ml of an distilled water solution containing 4 mg/kg of Me venom) and antivenom (intravenously 5 ml) were administered in six rabbits as group 3 animals. In group 4, rabbits received five ml of antivenom, 60 min after Me venom injection.
Results: In group 2, venom injection caused histopathological damages such as glomerular congestion, dilated vessels of interstitium and focal interstitial congestion in the kidney. It also increased creatinine and BUN levels 3 h after envenomation. Simultaneous administration of antivenom and venom prevented histopathological damage and marker changes. In group four, Immunotherapy decreased histopathological damages and prevented creatinine and BUN elevation at 3 h.
Conclusion: Polyvalent antivenom administration can prevent and neutralize nephrotoxic effects of Mesobuthus eupeus scorpion envenomation, if used at optimum conditions.
Methods: Twenty four rabbits were randomized into four groups: six rabbits in control group were received 1 ml distilled water subcutaneously (group 1). In group 2, sublethal dose of Me venom (4 mg/kg) was injected subcutaneously. Simultaneously venom (subcutaneously 1ml of an distilled water solution containing 4 mg/kg of Me venom) and antivenom (intravenously 5 ml) were administered in six rabbits as group 3 animals. In group 4, rabbits received five ml of antivenom, 60 min after Me venom injection.
Results: In group 2, venom injection caused histopathological damages such as glomerular congestion, dilated vessels of interstitium and focal interstitial congestion in the kidney. It also increased creatinine and BUN levels 3 h after envenomation. Simultaneous administration of antivenom and venom prevented histopathological damage and marker changes. In group four, Immunotherapy decreased histopathological damages and prevented creatinine and BUN elevation at 3 h.
Conclusion: Polyvalent antivenom administration can prevent and neutralize nephrotoxic effects of Mesobuthus eupeus scorpion envenomation, if used at optimum conditions.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
