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:: Volume 10, Issue 1 (January-February 2016) ::
IJT 2016, 10(1): 53-55 Back to browse issues page
Management of 2, 4- Dichlorophenoxyacetic Acid Intoxication by Hemodialysis: A Case Report
Mohammad Moshiri , Seyed Reza Mousavi , Leila Etemad
PhD.of Toxicology, Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. , etemadl@mums.ac.ir
Abstract:   (1689 Views)

Background: The herbicide 2, 4-dichlorophenoxyacetic acid (2, 4-D) can cause moderate to lethal poisoning. Although urine alkalization has been recommended as the main treatment, hemodialysis (HD) may be more effective in severe cases.

Case: On 24th June 2014, a 53- year-old man ingested a high amount of 40% 2, 4-D. He suffered from mouth and epigastric burning sensation, vomiting and nausea. He was treated, in Emam Reza’s Hospital of Mashhad University Of Medical Sciences, Mashhad , Iran,  with maintenance daily fluid infusion plus 10 meq/L NaHCO3. Up to 9 hours after exposure, he became progressively stuporous. He developed diarrhea and hypotension, BP=100/60, unresponsive to volume replacement therapy. He received regular hemodialysis (HD) with bicarbonate for three hours. At the end of HD, his blood pressure rose to 110/70 and the level of consciousness began to improve. Four hours later, he was fully conscious with stable blood pressure (130/80 mmHg).

Conclusion: HD may be an effective, safe and fast method for 2, 4-D high dose intoxication induced coma.

Keywords: 2, 4- dichlorophenoxyacetic acid, Alkaline diuresis, Hemodialysis, Herbicide intoxication, Iran.
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Moshiri M, Mousavi S R, Etemad L. Management of 2, 4- Dichlorophenoxyacetic Acid Intoxication by Hemodialysis: A Case Report. IJT. 2016; 10 (1) :53-55
URL: http://ijt.arakmu.ac.ir/article-1-416-en.html

Volume 10, Issue 1 (January-February 2016) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
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