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Volume 10, Issue 3 (May-June 2016)                   IJT 2016, 10(3): 1-5 | Back to browse issues page


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Barakizou H, Ben Rjeb Y, Gannouni S, Bayoudh F. Acute Drug Poisoning in Tunisian Children: About 150 Cases. IJT 2016; 10 (3) :1-5
URL: http://ijt.arakmu.ac.ir/article-1-465-en.html
1- Department of Pediatrics, Military hospital of Tunis, University Tunis El Manar, Tunis, Tunisie. , barakizouhager@yahoo.fr
2- Department of Pediatrics, Military hospital of Tunis, University Tunis El Manar, Tunis, Tunisie.
Abstract:   (5062 Views)

Background: Acute drug poisoning remains an important public health problem and represents the second most frequent accidental disease in children. In this study, we identified epidemiological and clinical features of children admitted for acute drug poisoning and related factors associated with suicidal poisoning.

Methods: We conducted a retrospective study in the Department of Pediatrics, the Military Hospital, Tunis, over a period of 8 years (2008-2014). Children aged less than 16 yr and admitted for acute drug poisoning were included. Cases of drug addiction were excluded. Two groups were compared: accidental poisoning / suicidal poisoning.

Results: We collected 150 cases. The ratio male / female was 1:1.2. The mean age was 4.3 yr. Poisoning was due to one drug in 82% of cases. Children were asymptomatic in 39% of cases, had digestive and neurologic symptoms respectively in 30% and 20% of cases, respectively. Psychotropics came in the first place (20%) followed by paracetamol (16%). Two groups were identified: accidental poisoning (74 %) and suicidal poisoning (26%). Four factors were significantly associated with suicidal poisoning: age &ge; 8 yr (P< 0.001, OR= 16.25, 95% IC : [6.44-40.95]), female gender (P=0.011, OR= 5.4, 95% IC: [2.09-13.91]), multiple drug intake (P < 0.001, OR= 9.42, 95% IC: [3.05-29.03]) and use of psychotropics (P= 0.003, OR=4.81, 95%IC: [2.06-11.26]) .

Conclusion: Two groups had to be distinguished: accidental and suicidal drug poisoning. The identification of their characteristics and their predisposing factors is necessary in order to take appropriate preventive actions.

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Type of Study: Research | Subject: Special

References
1. Jesslin J, Adepu R, Churi S. Assessment of prevalence and mortality incidences due to poisoning in a South Indian tertiary care teaching hospital. Indian J Pharm Sci 2010;72:587-91. [DOI:10.4103/0250-474X.78525]
2. Zarezadeh M, Bahrampour A. Poisoning Survey of Referred Children to Afzalipour Hospital in Kerman in 2009-2010. IJT. 2011; 4 (4) :397-401.
3. Gupta SK, Peshin SS, Srivastava A, Kaleekal T. A study of childhood poisoning at National Poisons Information Centre, All India Institute of Medical Sciences, New Delhi. J Occup Health 2003 May;45(3):191-6. [DOI:10.1539/joh.45.191]
4. Oliveira FF, Suchara EA. Epidemiological profile of exogenous poisoning in children and adolescents from a municipality in the state of Mato Grosso. Rev Paul Pediatr 2014; 32(4): 299–305. [DOI:10.1590/S0103-05822014000400004]
5. Cremer R, Mathieu-Nolf M. Épidémiologie des intoxications de l'enfant. Arch Pediatr 2004; 11: 677–9. [DOI:10.1016/j.arcped.2004.03.107]
6. Blake D, Dalton S, Gunja N. Transporting children with toxicological emergencies. Emerg Med Australas 2014;26(3):279–85. [DOI:10.1111/1742-6723.12221]
7. Woo JH, Ryoo F. Poisoning in Korean Children and Adolescents. Pediatr Gastroenterol Hepatol Nutr 2013;16(4): 233–9. [DOI:10.5223/pghn.2013.16.4.233]
8. Sadeghi Bojd S, Khajeh A. Chronological Variations of Children Poisoning Causes in Zahedan, South of Iran. Int J High Risk Behav Addict 2014; 3(3): e19223. [DOI:10.5812/ijhrba.19223]
9. Kumar MR, Kumar GP, Babu PR, Kumar SS, Subrahmanyam BV, Veeraprasad M, et al. A retrospective analysis of acute organophosphorus poisoning cases admitted to the tertiary care teaching hospital in South India. Ann Afr Med 2014;13(2):71–5. [DOI:10.4103/1596-3519.129876]
10. McGregor T, Parkar M, Rao S. Evaluation and management of common childhood poisonings. Am Fam Physician. 2009;79(5):397–403.
11. Ghribi F, Ouali F, Bouchaala H. Children's accidents in rural environment: study of 324 cases. Tunis Med 2003;81(2):86-93.
12. Zambolim CM, Oliveira TP, Hoffmann AN, Vilela CE, Neves D, dos Anjos FR, et al. Exogenous intoxications profile in a university hospital. Rev Med Minas Gerais 2008;18:5–10.
13. Belin-Rauscent A, Fouyssac M, Bonci A, Belin D. How Preclinical Models Evolved to Resemble the Diagnostic Criteria of Drug Addiction. Biopsych 2016: 79(1): 39-46. [DOI:10.1016/j.biopsych.2015.01.004]
14. Ben Hamida-Nouaili E, Ben Said A, Ouzini F, Bezzine A, Ben Hamida A, Marrakchi Z. Epidemiology of Domestic accidents of young children in Tunis: Impact of health professionals training on data collection quality. Tunis Med 2011; 89: 766 -8.
15. Rekik A, Zouari A, Khaldi O, Gargouri A, Triki A. Epidemiologic profile of accidents in Tunisian children. Pediatrie 1989;44(9):721-4.
16. Ram P, Kanchan T, Unnikrishnan B. Pattern of acute poisonings in children below 15 years - A study from Mangalore, South India. J Forensic Leg Med 2014; 25: 26e29.
17. Alije Keka, Ramosaj A, Toro H, Azemi M, Baloku A, Sylaj B, et al. Acute poisoning in children; changes over the years, data of pediatric clinic department of toxicology. JAD 2014; 56-8.
18. Jepsen F, Ryan M. Poisoning in children. Current Paediatrics 2005; 15: 563–8. [DOI:10.1016/j.cupe.2005.08.006]
19. Lin YR, Liu TH, Liu TA, Chang YJ, Chou CC, Wu HP. Pharmaceutical poisoning exposure and outcome analysis in children admitted to the pediatric emergency department. Pediatr Neonatol 2011;52(1):11-7. [DOI:10.1016/j.pedneo.2010.12.003]
20. Arroyo A, Rodrigo C, Marrón MT. Toxicological evaluation in the childhood. Med Clin (Barc) 2014;142 Suppl 2:43-6. [DOI:10.1016/S0025-7753(14)70071-5]
21. Andian N, Sarikayalar F. Pattern of acute poisonings in childhood in Ankara: What has changed in twenty years? Turk J Pediatric 2004;46(2):142-52.
22. Ben Rabeh R, Boukriss R, Ben Helel K, Hammami S, Issa K, Siala N, et al. Profil épidémiologique et législatif des intoxications médicamenteuses chez l'enfant Tunisien. Rev Mar Mal Enf 2014; 33 : 11-13
23. Nabeel Manzar, Syed Muhammed Ali Suad, and Sueda Shazeen Fatima. The study of etiological and demographic characteristics of acute household accidental poisoninig in children - a consecutive case series. Study from Pakistan. BMC Pediatrics 2010;20:28 [DOI:10.1186/1471-2431-10-28]
24. Yang CC, Wu JF, Ong HC, Kuo YP, Deng JF, Ger J. Children poisoning in Taiwan. Indian J Pediatr 1997;64(4):469-83. [DOI:10.1007/BF02737751]
25. Chevret L. Intoxications graves: prise en charge en réanimation pédiatrique. Arch Pediatr 2004; 11: 680-2 [DOI:10.1016/j.arcped.2004.03.035]
26. Watson WA, Litovitz TL, Rodgers GC Jr, Klein-Schwartz W, Youniss J, Rose SR, et al. 2002 annual report of the American Association of Poison Centers toxic exposure surveillance system. Am J Emerg Med 2003;21:353–421. [DOI:10.1016/S0735-6757(03)00088-3]
27. Olguin HJ, Gardu-o LB, Pérez JF, Bastida MA, Flores-Pérez C. Frequency of suicide attempts by ingestion of drugs seen at a tertiary care pediatric hospital in Mexico. J Popul Ther Clin Pharmacol 2011;18:e161-5.
28. Amami O, Aloulou J, Elleuch M, Aribi L. Suicide attempt in pupils and university students: A Tunisian case study of 61 cases. Tunis Med 2013; 91 : 175-8.
29. Delamare C, Martin Y, Blanchon C. Tentatives de suicide chez l'enfant de moins de 13 ans. Neuropsychiatr Enfance Adolesc 2007;55:41–51. [DOI:10.1016/j.neurenf.2007.01.006]
30. Stordeur C, Acquaviva E, Galdon L, Mercier JC, Titomanlio L, Delorme R. Tentatives de suicide chez les enfants de moins de 12 ans. Arch Pediatr 2015 ; 22 : 255-9. [DOI:10.1016/j.arcped.2014.12.004]
31. Giraud P, Fortanier C, Fabre G, Ghariani J, Guillermain Y, Rouviere N, et al. Tentatives de suicide : étude descriptive d'une cohorte de 517 adolescents de moins de 15 ans et 3 mois. Arch Pediatr 2013; 20:608–15. [DOI:10.1016/j.arcped.2013.03.024]
32. Brissaud O, Chevretb L, Claudet I. Intoxication grave par médicaments et/ou substances illicites admise en réanimation : spécificités pédiatriques. Réanimation 2006; 15 : 405–11. [DOI:10.1016/j.reaurg.2006.07.004]
33. Yates Kim M. Accidental poisoning in New Zealand. Emergency Medicine 2003; 15(3): 244–9. [DOI:10.1046/j.1442-2026.2003.00443.x]
34. Zakharov S, Navratil T, Pelclova D. Suicide attempts by deliberate self-poisoning in children and adolescents. Psychiatry Res 2013;210(1):302-7. [DOI:10.1016/j.psychres.2013.03.037]
35. Halayem S, Bouden A, Othman S, Halayem MB. Profil du suicidant en population clinique : une expérience tunisienne. Neuropsychiatr Enfance Adolesc 2010; 58: 120-5. [DOI:10.1016/j.neurenf.2009.06.002]

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