Write your message
Volume 11, Issue 5 (September-October 2017)                   IJT 2017, 11(5): 1-4 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghiasi F, Mirzargar S S, Ashrafihellan J. Histological Effects of Cadmium on Hepatopancreas and Gill in Cyprinus carpio. IJT. 2017; 11 (5) :1-4
URL: http://ijt.arakmu.ac.ir/article-1-537-en.html
1- Department of Fisheries, Faculty of Natural Resources, University of Kurdistan, Sanandaj, Iran. , f.ghiasi@uok.ac.ir
2- Department of Aquatic Animal Health, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
3- Department of Pathology, Veterinary college, University of Tabriz, Tabriz, Iran.
Abstract:   (3485 Views)
Background: Histological studies in organs like hepatopancreas and gill of the freshwater fish, Cyprinus carpio, were made to assess tissue damage due to sub-lethal concentration of cadmium after a long exposure period.
Methods: This study was conducted in University of Tehran, in 2013. The fish were divided into two groups in 1000 litre fiberglass tanks supplied with dechlorinated water [hardness 302.6 mg CaCo3/l, pH 7, O2 7.8 mg/L and temperature 15 ± 2 ºC] and continuous aeration. Group 1 was without any cadmium considered as control group. Group 2 was exposed to 30 ppb CdCl2 (Merck) containing 7.8 ppb cadmium. The tissue samples from: hepatopancreas, gill were collected 30 days post exposure and processed by histological procedures.
Results: The main lesions in cadmium exposed groups were: (a) pancreatitis necrosis in endocrine part of pancreas (b) cholangitis and necrosis in liver parenchyma (c) hypertrophy, fusion and telangiectasia in secondary lamellae
Conclusion: Cadmium chloride at low concentration can induce pathological alterations in hepatopancreas and gill of common carp.
Full-Text [PDF 429 kb]   (1324 Downloads)    
Type of Study: Research | Subject: Special

1. Randi A, Monserrat J, Rodriguez E, Romano L. Histopathological effects of cadmium on the gills of the freshwater fish, Macropsobrycon uruguayanae Eigenmann (Pisces, Atherinidae). J Fish Dis1996;19(4):311-22. [DOI:10.1111/j.1365-2761.1996.tb00709.x]
2. Kori-Siakpere O, Ake J, Avworo U. Sublethal effects of cadmium on some selected haematological parameters of Heteroclarias (a hybrid of Heterobranchus bidorsalis and Clarias gariepinus). Int.j.zool.res 2006;2(1):77-83.
3. Ghiasi F, Mirzargar S, Badakhshan H, Shamsi S. Effects of low concentration of cadmium on the level of lysozyme in serum, leukocyte count and phagocytic index in Cyprinus carpio under the wintering conditions. J Fisheries Aqua Sci 2010;5(2):113-9. [DOI:10.3923/jfas.2010.113.119]
4. Ghiasi F, Mirzargar S. Pathological effects of cadmium and efficiency of natural zeolite, Clinoptilolite, to reduce the cadmium toxicity in common carp and its ability to remove Cadmium from contaminated water. Res J Vet Pract 2015;3(2):36-40. [DOI:10.14737/journal.rjvp/2015/]
5. Singhal R, Jain M. Cadmium-induced changes in the histology of kidneys in common carp, Cyprinus carpio (Cyprinidae). B Environ Contam Toxicol 1997;58(3):456-62. [DOI:10.1007/s001289900356]
6. Van Dyk JC, Pieterse G, Van Vuren J. Histological changes in the liver of Oreochromis mossambicus (Cichlidae) after exposure to cadmium and zinc. Ecotoxicol Environ Saf 2007;66(3):432-40. [DOI:10.1016/j.ecoenv.2005.10.012]
7. Thophon S, Kruatrachue M, Upatham E, Pokethitiyook P, Sahaphong S, Jaritkhuan S. Histopathological alterations of white seabass, Lates calcarifer, in acute and subchronic cadmium exposure. Environ Pollut 2003;121(3):307-20. [DOI:10.1016/S0269-7491(02)00270-1]
8. Jia X, Zhang H, Liu X. Low levels of cadmium exposure induce DNA damage and oxidative stress in the liver of Oujiang colored common carp Cyprinus carpio var. color. Fish Physiol Biochem 2011;37(1):97-103. [DOI:10.1007/s10695-010-9416-5]
9. Schwartz GG, Reis IM. Is cadmium a cause of human pancreatic cancer? Cancer Epidemiol Biomarkers Prev 2000;9(2):139-45.
10. Suresh A, Sivaramakrishna B, Radhakrishnaiah K. Patterns of cadmium accumulation in the organs of fry and fingerlings of freshwater fish Cyprinus carpio following cadmium exposure. Chemosphere 1993;26(5):945-53. [DOI:10.1016/0045-6535(93)90369-G]
11. Witeska M, Kondera E, Szczygielska K. The effects of cadmium on common carp erythrocyte morphology. Pol J Environ Stud. 2011;20:783-8.
12. Bernet D, Schmidt H, Meier W, Burkhardt‐Holm P, Wahli T. Histopathology in fish: proposal for a protocol to assess aquatic pollution.J Fish Dis 1999;22(1):25-34. [DOI:10.1046/j.1365-2761.1999.00134.x]
13. Johnson LL, Stehr CM, Olson OP, Myers MS, Pierce SM, Wigren CA, et al. Chemical contaminants and hepatic lesions in winter flounder (Pleuronectes americanus) from the Northeast Coast of the United States. Environ Sci Techno 1993;27(13):2759-71. [DOI:10.1021/es00049a015]
14. Bais U, Lokhande M. Effect of cadmium chloride on histopathological changes in the freshwater fish Ophiocephalus striatus (Channa). Int J Zoological Res 2012;8(1):23-32. [DOI:10.3923/ijzr.2012.23.32]
15. Radhakrishnan M, Hemalatha S. Sublethal toxic effects of cadmium chloride to liver of freshwater fish Channa striatus (Bloch). Ame-Euras J Toxicol Sci 2010;2(1):54-6.
16. Ghiasi F, Mirzargar S, Badakhshan H, Amoli J. Influence of Iranian natural zeolite on accumulation of cadmium in cyprinus carpio tissues following exposure to low concentration of cadmium. Asian J Animal Vet Adv 2011;6(6):636-41. [DOI:10.3923/ajava.2011.636.641]
17. Klaassen CD, Liu J, Diwan BA. Metallothionein protection of cadmium toxicity. Toxicol Appl Pharmacol 2009;238(3):215-20. [DOI:10.1016/j.taap.2009.03.026]
18. Nordberg GF. Cadmium and health in the 21st century–historical remarks and trends for the future. Biometals 2004;17(5):485-9. [DOI:10.1023/B:BIOM.0000045726.75367.85]
19. Park JD, Liu Y, Klaassen CD. Protective effect of metallothionein against the toxicity of cadmium and other metals. Toxicol 2001;163(2):93-100. [DOI:10.1016/S0300-483X(01)00375-4]
20. Mieiro C, Bervoets L, Joosen S, Blust R, Duarte A, Pereira M, et al. Metallothioneins failed to reflect mercury external levels of exposure and bioaccumulation in marine fish–Considerations on tissue and species specific responses. Chemosphere 2011;85(1):114-21. [DOI:10.1016/j.chemosphere.2011.05.034]

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2021 CC BY-NC 4.0 | Iranian Journal of Toxicology

Designed & Developed by : Yektaweb