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Volume 11, Issue 4 (July-August 2017)
IJT 2017, 11(4): 19-26 |
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Islam M T, Talukder A K, Talukder M, Amin M R, Alam K J, Haider M G. Mercury Intoxication in Rats: Iron and Vitamin B6 as A Potential Therapy. IJT 2017; 11 (4) :19-26
URL: http://ijt.arakmu.ac.ir/article-1-570-en.html
URL: http://ijt.arakmu.ac.ir/article-1-570-en.html
Mohammad Taimur Islam * 
1, Anup Kumar Talukder2 , Milton Talukder3 , Mohammad Rohul Amin3 , Khondoker Jahengir Alam4 , Mohammad Golam Haider5
1, Anup Kumar Talukder2 , Milton Talukder3 , Mohammad Rohul Amin3 , Khondoker Jahengir Alam4 , Mohammad Golam Haider5
1- Department of Pathobiology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh. , shiplu_bau@yahoo.com
2- Department of Gynecology, Obstetrics and Reproductive Health, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
3- Department of Physiology and Pharmacology, Patuakhali Science and Technology University, Babugonj, Barisal, Bangladesh.
4- Department of Pathology and Parasitology, Patuakhali Science and Technology University, Babugonj, Barisal, Bangladesh.
5- Department of Pathobiology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
2- Department of Gynecology, Obstetrics and Reproductive Health, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
3- Department of Physiology and Pharmacology, Patuakhali Science and Technology University, Babugonj, Barisal, Bangladesh.
4- Department of Pathology and Parasitology, Patuakhali Science and Technology University, Babugonj, Barisal, Bangladesh.
5- Department of Pathobiology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh.
Abstract: (4508 Views)
Background: Mercury in any form is poisonous and mercury toxicity most commonly affects the nervous, gastrointestinal (GI) and urinary systems. The aim of this study was to investigate the specific effect associated with mercury toxicity and to evaluate the effectiveness of iron and vitamin B6 supplement on mercury-induced toxicities in rats.
Methods: This experiment was performed on 25 rats. All rats were randomly divided into five equal groups (5×5). Toxic signs and body weight change, hematological parameters like total erythrocyte count (TEC), total leukocyte count (TLC), hemoglobin content (Hb%) and packed cell volume (PCV) and postmortem changes in rats were investigated.
Results: Rats treated with mercury intoxication showed severe toxic signs and significantly (P<0.01) reduced TEC, TLC, Hb content and PCV. However, rats treated with mercury intoxication in combination with iron and vitamin B6 showed physiological levels of hematological parameters. Mercury intoxication induced the congestion and necrosis in lung, liver, heart and kidney, whereas combined use of mercury intoxication, iron and vitamin B6 recovered the condition.
Conclusion: Combined use of iron and vitamin B6 is highly protective against mercury toxicity.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
