Volume 11, Issue 4 (July-August 2017)                   IJT 2017, 11(4): 19-26 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Islam M T, Talukder A K, Talukder M, Amin M R, Alam K J, Haider M G. Mercury Intoxication in Rats: Iron and Vitamin B6 as A Potential Therapy. IJT. 2017; 11 (4) :19-26
URL: http://ijt.arakmu.ac.ir/article-1-570-en.html
Department of Pathobiology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur, Bangladesh. , shiplu_bau@yahoo.com
Abstract:   (1012 Views)

Background: Mercury in any form is poisonous and mercury toxicity most commonly affects the nervous, gastrointestinal (GI) and urinary systems. The aim of this study was to investigate the specific effect associated with mercury toxicity and to evaluate the effectiveness of iron and vitamin B6 supplement on mercury-induced toxicities in rats.

Methods: This experiment was performed on 25 rats. All rats were randomly divided into five equal groups (5×5). Toxic signs and body weight change, hematological parameters like total erythrocyte count (TEC), total leukocyte count (TLC), hemoglobin content (Hb%) and packed cell volume (PCV) and postmortem changes in rats were investigated.

Results: Rats treated with mercury intoxication showed severe toxic signs and significantly (P<0.01) reduced TEC, TLC, Hb content and PCV. However, rats treated with mercury intoxication in combination with iron and vitamin B6 showed physiological levels of hematological parameters. Mercury intoxication induced the congestion and necrosis in lung, liver, heart and kidney, whereas combined use of mercury intoxication, iron and vitamin B6 recovered the condition.

Conclusion: Combined use of iron and vitamin B6 is highly protective against mercury toxicity.

Full-Text [PDF 138 kb]   (677 Downloads)    
Type of Study: Research | Subject: General

1. Officioso A, Tortora F, Manna C. Nutritional Aspects of Food Toxicology: Mercury Toxicity and Protective Effects of Olive Oil Hydroxytyrosol. J Nutr Food Sci 2016;6(539):2.
2. Clifton JC. Mercury exposure and public health. Pediatr Clin North Am 2007;54(2):237-69. [DOI:10.1016/j.pcl.2007.02.005]
3. Qiu Y-W, Wang W-X. Comparison of mercury bioaccumulation between wild and mariculture food chains from a subtropical bay of Southern China. Environ Geochem Health 2016;38(1):39-49. [DOI:10.1007/s10653-015-9677-0]
4. Patrick L. Public health hazards of mercury poisoning. Altern Med Rev 2002;7(6):456-71.
5. Kim K-H, Kabir E, Jahan SA. A review on the distribution of Hg in the environment and its human health impacts. J Hazard Mater 2016;306:376-85. [DOI:10.1016/j.jhazmat.2015.11.031]
6. Kavitha AV, Jagadeesan G. Influence of Tribulus terrestris extract of mercury intoxicated stomach of rats. J Exp Zoology 2002;5(2):161-6.
7. Nagar R, Bhattacharya L. Effect of mercuric chloride on testicular activities in mice, Musculus albinus. J Environ Biol 2001;22(1):15-8.
8. Margarat A, Jagadeesan G. Effect of Tribulus terrestris extract on mercuric chloride poisoning in mice, Mus musculus-a biochemical study. Indian J Environ Toxicol 2000;10(1):14-5.
9. Huang Y-L, Lin T-H. Effect of acute administration of mercuric chloride on the disposition of copper, zinc, and iron in the rat. Biol Trace Elem Res 1997;58(1):159-68. [DOI:10.1007/BF02910676]
10. Zalups RK. Reductions in renal mass and the nephropathy induced by mercury. Toxicol Appl Pharmaco 1997;143(2):366-79. [DOI:10.1006/taap.1996.8084]
11. Davis LE, Wands JR, Weiss SA, Price DL, Girling EF. Central nervous system intoxication from mercurous chloride laxatives: quantitative, histochemical, and ultrastructural studies. Arch Neuro 1974;30(6):428-31. [DOI:10.1001/archneur.1974.00490360004002]
12. Goyer R. Toxic effects of metals. In: Amdur MO, Doull JD, Klassen CD, editors. Casarett and Doull's Toxicology. New York: Pergamon Press; 1991. p. 623-80.
13. Carocci A, Rovito N, Sinicropi MS, Genchi G. Mercury toxicity and neurodegenerative effects. In: Reviews of environmental contamination and toxicology. Springer International Publishing; 2014.p. 1-18. [DOI:10.1007/978-3-319-03777-6_1]
14. Coppedè F, Migliore L. Evidence linking genetics, environment, and epigenetics to impaired DNA repair in Alzheimer's disease. J Alzheimer's Dis 2010;20(4):953-66. [DOI:10.3233/JAD-2010-1415]
15. Commissaris R, Cordon J, Sprague S, Keiser J, Mayor G, Rech R. Behavioral changes in rats after chronic aluminum and parathyroid hormone administration. Neurobehavi Toxicol Teratol 1982;4(3):403-10.
16. Fawer R, De Ribaupierre Y, Guillemin M, Berode M, Lob M. Measurement of hand tremor induced by industrial exposure to metallic mercury. Br J Indust Med 1983;40(2):204-8. [DOI:10.1136/oem.40.2.204]
17. Piikivi L, Hänninen H. Subjective symptoms and psychological performance of chlorine-alkali workers. Scand J Work Environ Health 1989:69-74. [DOI:10.5271/sjweh.1880]
18. Ngim C, Foo S, Boey K, Jeyaratnam J. Chronic neurobehavioural effects of elemental mercury in dentists. Br J Ind Med 1992;49(11):782-90. [DOI:10.1136/oem.49.11.782]
19. Virtanen JK, Rissanen TH, Voutilainen S, Tuomainen T-P. Mercury as a risk factor for cardiovascular diseases. J Nutr Biochem 2007;18(2):75-85. [DOI:10.1016/j.jnutbio.2006.05.001]
20. Lamberg S, Rothstein R. Laboratory manual of hematology and urine analysis 1st edition. AG publishing Company Inc, Westport, Conencticut, USA; 1977.
21. Chauhan HV, SS Roy. Poultry Diseases and Treatment. New Delhi, India: New Age International (P) Limited; 2008.
22. Kirpal S, Sidhu. Mercury toxicology and its use in dental amalgams. Inter J Toxicol Occup Environ1993;2(1):21-2.
23. Moniruzzaman M. Effect of selenium and zinc supplementation on mercury intoxication in rats. Thesis for MSc. Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, 2004.
24. Hossain MM. Effect of vitamin E and vitamin C supplementation on mercury intoxication in rats. Thesis for MSc. Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, 2005.
25. Hernández LE, Sobrino-Plata J, Montero-Palmero MB, Carrasco-Gil S, Flores-Cáceres ML, Ortega-Villasante C, et al. Contribution of glutathione to the control of cellular redox homeostasis under toxic metal and metalloid stress. J Exp Bot 2015;66(10):2901-11. [DOI:10.1093/jxb/erv063]
26. Naganuma A, Ishii Y, Imura N. Effect of administration sequence of mercuric chloride and sodium selenite on their fates and toxicities in mice. Ecotoxicol Environ Saf 1984;8(6):572-80. [DOI:10.1016/0147-6513(84)90017-4]
27. Thangam Y, Umavathi S, Vysakh V. Investigation of Mercury Toxicity in Haematological Parameters to Fresh Water Fish "Cyprinus carpio". Int J Sci Res 2016;5(2):1004-11.
28. Ribeiro CO, Neto FF, Mela M, Silva P, Randi MAF, Rabitto I, et al. Hematological findings in neotropical fish Hoplias malabaricus exposed to subchronic and dietary doses of methylmercury, inorganic lead, and tributyltin chloride. Environ Research 2006;101(1):74-80. [DOI:10.1016/j.envres.2005.11.005]
29. Arvind M, Bhargava S, Vineeta J. Mercury induced some hematological changes in Channa striatus. Int J Toxicol Occup Environ 1993;2(1):29-30.
30. Bersenyi A, Fekete SG, Szőcs Z, Berta E. Effect of ingested heavy metals (Cd, Pb and Hg) on haematology and serum biochemistry in rabbits. Acta Vet Hung 2003;51(3):297-304. [DOI:10.1556/AVet.51.2003.3.5]
31. Aslanturk A, Uzunhisarcikli M, Kalender S, Demir F. Sodium selenite and vitamin E in preventing mercuric chloride induced renal toxicity in rats. Food Chemi Toxicol 2014;70:185-90. [DOI:10.1016/j.fct.2014.05.010]

Add your comments about this article : Your username or Email:

Send email to the article author

© 2019 All Rights Reserved | Iranian Journal of Toxicology

Designed & Developed by : Yektaweb