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Volume 11, Issue 4 (July-August 2017)                   IJT 2017, 11(4): 51-56 | Back to browse issues page

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Ebadollahi-Natanzi A, Arab-Rahmatipour G. Psyllium Together with Allopurinol Can Efficiently Reduce the Increased Serum Level of Uric Acid, Creatinine and Urea: A Case Report. IJT. 2017; 11 (4) :51-56
URL: http://ijt.arakmu.ac.ir/article-1-594-en.html
1- Department of Medicinal Plants, Imam Khomeini Higher Education Center Agriculture Research, Education and Extension Organization (AREEO), Karaj, Iran. , ebad@ihec.ir
2- Department of Biochemistry, Farabi Hospital Laboratory, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:   (4293 Views)

Background: Medicinal plants have potential to affect therapeutically procedures. In this study, the therapeutical effects of psyllium on a patient with highly increased level of uric acid, creatinine, and urea have been studied.

Case Report: The case was a 50-yr-old woman affected by diabetes mellitus. Her blood biochemical analyses, showed an increased levels of uric acid (9.70±0.30mg/dL), urea (93.00± 3.60mg/dL) and creatinine (2.30±0.20 mg/dL). She was taken allopurinol (100 mg /daily) followed by consumption of 5 gr/daily from psyllium seeds which continued for two consecutive weeks. Then, the levels of uric acid, urea and creatinine were reached the normal value so that their measured levels were 5.60±0.26; 34.00±1.73 and 1.10±0.10 mg/dL, respectively. Psyllium together with allopurinol could also reduce cholesterol and triglyceride levels in this patient.

Conclusion: We can conclude that psyllium along with allopurinol can synergistically decrease the increased levels of uric acid, creatinine, and urea.

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Type of Study: case report | Subject: General

1. Kunle OF, Egharevba HO, Ahmadu PO. Standardization of herbal medicines- A review. Int J Biodvers Conserv 2012; 4(3): 101-12. [DOI:10.5897/IJBC11.163]
2. Wu Y, Ou-Yang JP, Wu K, Wang Y, Zhou YF, Wen CY. Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B. Acta Pharmacol Sin 2005; 26 (3): 345 - 52. [DOI:10.1111/j.1745-7254.2005.00062.x]
3. Jalilzadeh-Amin G, Maham M. Antidiarrheal activity and acute oral toxicity of Mentha longifolia L. essential oil. Avicenna J Phytomed 2015; 5(2):128-37.
4. Ebadollahinatanzi A, Arabrahmatipor G. The protective effects resulting from a combination of three medicinal plants on liver injury due to carbamazepine drug: A case report. Toxicol Lett 2016; 258S:S105-6. [DOI:10.1016/j.toxlet.2016.06.1443]
5. Ebadollahi-Natanzi A, Hajar H, Arab-Rahmatipour G. Determination of total phenolic content and free radical scavenging activity of total extract from the plant Rorippa sylvestris. Iran J Pharm Res 2014; 13(2): 35-6.
6. Arab-Rahmatipour G, Hajar H, Arab-Rahmatipour M, Moradi H. The study of anti-inflammatory effects of lavender, eucalyptus and walnut oil extract compounds. Iran J Pharm Res 2016; 15:47-8.
7. Ebadollahi Natanzi A, Ghahremani MH, Monsef-Esfahani HR, Minaei B, Nazarian H, Sabzevari O. An experimental model for study of the hepatoprotective activity of Nasturtium officinale (Watercress) against acetaminophen toxicity using in situ rat liver system. Eur J Sci Res 2009;38(4):556-64.
8. Ebadollahi Natanzi AR, Ghahremani M, Esfehani HM, Minaei M, Nazarian H, Sabzevari O. Evaluation of antihepatotoxic effect of watercress extract and its fractions in rats. Int J Pharmacol 2010; 6(6): 896-902. [DOI:10.3923/ijp.2010.896.902]
9. Pittler M, Ernst E. Complementary therapies for reducing body weight: a systematic review.Int J Obes 2005; 29(9): 1030-8. [DOI:10.1038/sj.ijo.0803008]
10. Pacher P, Nivorozhkin A, Szabó C. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Res 2006; 58 (1): 87–114. [DOI:10.1124/pr.58.1.6]
11. Chung WH, Wang CW, Dao RL. Severe cutaneous adverse drug reactions. J Dermatol 2016; 43 (7): 758–66. [DOI:10.1111/1346-8138.13430]
12. Gliozzi M, Malara N, Muscoli S, Mollace V. The treatment of hyperuricemia. Int J Cardiol 2016; 213:23-7. [DOI:10.1016/j.ijcard.2015.08.087]
13. Haidari F, Keshavarz SA, Rashidi MR, Mahboob SA, Eshraghian MR, Shahi MM. Effects of quercetin and kaempferol versus allopurinol on serum uric acid levels, biomarkers of oxidative stress and hepatic xanthine oxidase/xanthine dehydrogenase activity in hyperuricemic rats. Pharm Sci 2009; 14 (4):301- 9.
14. Zargari A. Medical plants. 6th ed. Tehran: Tehran University Publication; 1997.p.193-205.
15. Libster M. Herb guide for nurses. Delmar, Thomson Learning. Inc USA. 2002:450-7.
16. Rodriguez-Moran M, Guerrero-Romero F, Lazcano-Burciaga G. Lipid and glucose lowering efficacy of Plantago psyllium in type II diabetes. J Diabetes Complications 1998; 12(5):273-8. [DOI:10.1016/S1056-8727(98)00003-8]
17. Sierra M, Garcia JJ, Fernandez N, Diez MJ, Calle AP. Therapeutic effects of psyllium in type 2 diabetic patients. Eur J Clin Nutr 2002; 56(9):830-42. [DOI:10.1038/sj.ejcn.1601398]
18. Levinson DJ, Becker MA. Clinical gout and the pathogenesis of hyperuricemia. In: McCarty DJ, Koopman WJ, editors. arthritis and allied conditions. Philadelphia: Lea & Febiger; 1993.p.1773–805.
19. Ziai SA, Larijani B, Akhoondzadeh S, Fakhrzadeh H, Dastpak A, Bandarian F, et al. Psyllium decreased serum glucose and glycosylated hemoglobin significantly in diabetic outpatients. J Ethnopharmacol 2005;102(2):202-7. [DOI:10.1016/j.jep.2005.06.042]
20. Nguyen MTT, Awale S, Tezuka Y, Tran QL, Watanabe H, Kadota S. Xanthine oxidase inhibitory activity of Vietnamese medicinal plants. Biol Pharm Bull 2004; 27(9): 1414- 21. [DOI:10.1248/bpb.27.1414]
21. Strazzullo P, Puig JG. Uric acid and oxidative stress: relative impact on cardiovascular risk. Nutr Metab Cardiovasc Dis 2007; 17(6): 409- 14. [DOI:10.1016/j.numecd.2007.02.011]
22. Maia L, Duarte RO, Freire AP, Moura JJG, Mira L. NADH oxidase activity of rat and human liver xanthine oxidoreductase: potent role in superoxide production. J Biol Inorg Chem 2007; 12(6):777-87. [DOI:10.1007/s00775-007-0229-7]
23. Nguyen MTT, Awale S, Tezuka Y, Ueda J Y, Tran Q. Kadota S. Xanthine oxidase inhibitors from the flowers of Chrysanthemum sinense. Planta Medica 2006;72(1):46-51. [DOI:10.1055/s-2005-873181]
24. Ebadollahinatanzi A, Moghadasi H. Hydrogen peroxide scavenging activity of two different infusions made from black tea. Toxicol lett 2016(258):S192-S3. [DOI:10.1016/j.toxlet.2016.06.1706]
25. Chiang LC, Chiang W, Chiang MY, Ng LT, Lin CC. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med 2003; 31(1): 37-46. [DOI:10.1142/S0192415X03000825]
26. Tewari D, Anjum N, Tripathi YC. Phytochemistry and pharmacology of plantago ovata: a natural source of laxative medicine. World J Pharmaceut Res 2014;3(9):361-72.
27. Bayless TM, Hanauer SB. Advanced Therapy of Inflammatory Bowel Disease: Ulcerative Colitis: PMPH-USA; 2011.p. 735-44.
28. Van Hoorn DE, Nijveldt RJ, Van Leeuwen PA, Hofman Z, M'Rabet L, De Bont DB, et al. Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids. Eur J Pharmacol 2002;451(2):111-8. [DOI:10.1016/S0014-2999(02)02192-1]
29. Cos P, Ying L, Calomme M, Hu JP, Cimanga K, Van Poel B, et al. Structure− activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers. J Nat Prod 1998;61(1):71-6. [DOI:10.1021/np970237h]

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