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:: Volume 11, Issue 6 (November-December 2017) ::
IJT 2017, 11(6): 43-47 Back to browse issues page
Response of Melanomacrophage Centers in Yellowfin Seabream (Acanthopagrus latus) Immune Organs as an Immunohistological Biomarker in Short-term Exposure to Phenanthrene
Mehrnaz Shirmohammadi , Mohammad Taghi Ronagh , Negin Salamat , Abdolali Movahedinia , Gholamreza Hamidian
Abstract:   (80 Views)
Background: The aim of this study was to assess the changes in plasma levels of antioxidant enzymes and melano-macrophage centers (MMCs) in immune tissues as biomarkers of yellowfin seabream (Acanthopagrus latus) exposed to phenanthrene (Phe) for 14 days.
Methods: The research was carried out at Khorramshahr University of Marine Science and Technology, Khorramshahr, Iran in Jan 2016. Thirty-six immature fish were intraperitoneally injected with coconut oil (10 μl/g-bw) containing Phe (70mg/kg-bw) and compared with control group (without injection). Then tissue and blood samples were obtained at 1, 4, 7 and 14 d after injection.
Results: The SOD and CAT activity showed a significant decrease in fish exposed to Phe up to day 7, then activity increased at day 14 in Phe-treated fish (P<0.05). The size and number of MMCs in treated fish in spleen and head kidney were higher than control.
Conclusion: Changes in these parameters (SOD, CAT, and MMCs) might be used as useful biomarkers for evaluating immunosuppressive Phe in fish.
Keywords: Antioxidant Enzymes, Melano-Macrophage Centers, Phenanthrene, Yellowfin Seabream
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Type of Study: Research | Subject: General
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Shirmohammadi M, Ronagh M T, Salamat N, Movahedinia A, Hamidian G. Response of Melanomacrophage Centers in Yellowfin Seabream (Acanthopagrus latus) Immune Organs as an Immunohistological Biomarker in Short-term Exposure to Phenanthrene. IJT. 2017; 11 (6) :43-47
URL: http://ijt.arakmu.ac.ir/article-1-611-en.html
Volume 11, Issue 6 (November-December 2017) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
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