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Volume 12, Issue 1 (January-Fabruary 2018)                   IJT 2018, 12(1): 39-46 | Back to browse issues page

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Nair N, Madhyastha S, Chitti P, Joy T, Blossom V. Does Chronic Administration of Sodium Valproate to Juvenile Rats Induce Movement Disorder and Cognitive Dysfunction during Adulthood?. IJT. 2018; 12 (1) :39-46
URL: http://ijt.arakmu.ac.ir/article-1-626-en.html
1- Department of Anatomy, Kasturba Medical College, Manipal University, Mangalore, India.
2- Department of Anatomy, Faculty of Medicine, Kuwait University, Jabriya, Kuwait. , madhyast@yahoo.com
Abstract:   (1964 Views)
Background: Children with seizure disorder are often treated with sodium valproate (SV) on long-term basis. SV acts mainly through gamma amino butyric acid pathways, reducing the excitatory neurotransmission and modifying the monoamine concentration. Altered monoamine concentration by SV is expected to cause movement disorder and cognitive dysfunction, considered reversible after the withdrawal of treatment, but some claim it to be irreversible. It is not clear whether such adverse effects continue during adulthood. The aim of this study was to investigate whether chronic administration of SV in juvenile rats causes movement disorder and cognitive dysfunction during their early adulthood.
Methods: Sixteen-day-old male Wistar rats from the central animal house, KMC, Mangalore, India in 2015, received either 200 or 400 mg/kg dose of SV for 45 consecutive days and another group served as control. Thirty days after discontinuation of the drug, at postnatal day 90, the rats were tested for movement disorder and cognitive function.
Results: Chronic SV treatment in juvenile rats resulted in slow movement, tremors during adulthood but did not affect muscle tone, locomotor and exploratory activities. It also caused cognitive dysfunction in adult rats.
Conclusion: Despite the reported safety of chronic SV therapy, its adverse effects such as Parkinsonism symptoms or cognitive dysfunctions should be of concern in all young patients treated with SV for many years. Persistence of cognitive impairment, tremors and generalized slow movement during adulthood after cessation of treatment that was observed in this study, warrants a close monitoring system in children who receive long-term sodium valproate.
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Type of Study: Research | Subject: General

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