Write your message
Volume 12, Issue 4 (July-August 2018)                   IJT 2018, 12(4): 25-30 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Srivastava B D, Srivastava M, Srivastav S K, Suzuki N, Srivastav A K. Cypermethrin-Induced Liver Histopathology in Rat: Protective Role of Jamun Seed and Orange Peel Extracts. IJT. 2018; 12 (4) :25-30
URL: http://ijt.arakmu.ac.ir/article-1-689-en.html
1- Department of Zoology, DDU Gorakhpur University, Gorakhpur, India.
2- Department of Chemistry, Digvijai Nath P.G. College, Gorakhpur, India.
3- PhD of Environmental Toxicology, Institute of Nature and Environmental Technology, Kanazawa University, Ogi, Noto-cho, Ishikawa, Japan.
4- Department of Zoology, DDU Gorakhpur University, Gorakhpur, India. , ajaiksrivastav@hotmail.com
Abstract:   (1410 Views)
We evaluated ameliorative effects of Jamun seed and orange peel extracts on liver toxicity in cypermethrin exposed rat.
Methods: Rats were given following treatments daily for 30 d:
Group A: Control
Group B: Rats received cypermethrin
Group C: These rats received cypermethrin and Jamun seed extract simultaneously
Group D: These rats received cypermethrin and orange peel extract simultaneously
Group E: Rats received orange peel extract
Group F: Rats received Jamun seed extract
In respective groups dose of cypermethrin, Jamun seed and orange peel extract were 25 mg/ kg body wt, 200 mg/kg body wt and 200 mg/kg body wt, respectively. Liver was fixed for light and electron microscopic studies.
Results: After 15 d cypermethrin or cypermethrin+JSE or cypermethrin+OPE treatment hepatocytes exhibited increased cell size, nuclei became more hyperchromatic and hypertrophied. Degeneration of nuclei and dilatation of sinusoids have been noticed. After 30 d cypermethrin treatment hepatocytes exhibit more pronounced hypertrophy with hyperchromatic nuclei. Few hepatocytes exhibit nuclei with irregular boundaries. Hepatocytes show foamy cytoplasm and few vacuoles. Focal necrosis visible at certain places. Binucleated cells are also encountered. In cypermethrin+JSE and cypermethrin+OPE treated rats, hepatocytes exhibit hypertrophy, hyperchromatic nuclei and dilatation of sinusoids. Degeneration of hepatocytes are seen at some places, however, focal necrosis is not seen in these groups. No noticeable histological alterations are seen in orange peel extract (group E) and jamun seed extract (group F) treated rats.
Conclusion: Cypermethrin induced hepatic toxicity can be protected by treatment with Jamun seed and orange peel extract.
Full-Text [PDF 2652 kb]   (492 Downloads)    
Type of Study: Research | Subject: General

Add your comments about this article : Your username or Email:

Send email to the article author

© 2020 All Rights Reserved | Iranian Journal of Toxicology

Designed & Developed by : Yektaweb