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:: Volume 12, Issue 4 (July-August 2018) ::
IJT 2018, 12(4): 25-30 Back to browse issues page
Cypermethrin-Induced Liver Histopathology in Rat: Protective Role of Jamun Seed and Orange Peel Extracts
Babita Deep Srivastava , Manish Srivastava , Sunil Kumar Srivastav , Nobuo Suzuki , Ajai Kumar Srivastav *
Department of Zoology, DDU Gorakhpur University, Gorakhpur, India. , ajaiksrivastav@hotmail.com
Abstract:   (27 Views)
We evaluated ameliorative effects of Jamun seed and orange peel extracts on liver toxicity in cypermethrin exposed rat.
Methods: Rats were given following treatments daily for 30 d:
Group A: Control
Group B: Rats received cypermethrin
Group C: These rats received cypermethrin and Jamun seed extract simultaneously
Group D: These rats received cypermethrin and orange peel extract simultaneously
Group E: Rats received orange peel extract
Group F: Rats received Jamun seed extract
In respective groups dose of cypermethrin, Jamun seed and orange peel extract were 25 mg/ kg body wt, 200 mg/kg body wt and 200 mg/kg body wt, respectively. Liver was fixed for light and electron microscopic studies.
Results: After 15 d cypermethrin or cypermethrin+JSE or cypermethrin+OPE treatment hepatocytes exhibited increased cell size, nuclei became more hyperchromatic and hypertrophied. Degeneration of nuclei and dilatation of sinusoids have been noticed. After 30 d cypermethrin treatment hepatocytes exhibit more pronounced hypertrophy with hyperchromatic nuclei. Few hepatocytes exhibit nuclei with irregular boundaries. Hepatocytes show foamy cytoplasm and few vacuoles. Focal necrosis visible at certain places. Binucleated cells are also encountered. In cypermethrin+JSE and cypermethrin+OPE treated rats, hepatocytes exhibit hypertrophy, hyperchromatic nuclei and dilatation of sinusoids. Degeneration of hepatocytes are seen at some places, however, focal necrosis is not seen in these groups. No noticeable histological alterations are seen in orange peel extract (group E) and jamun seed extract (group F) treated rats.
Conclusion: Cypermethrin induced hepatic toxicity can be protected by treatment with Jamun seed and orange peel extract.
Keywords: Cypermethrin, Hepatocytes, Pyrethroid, Jamun Seed Extract, Liver, Orange Peel Extract Liver
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Type of Study: Research | Subject: General
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Srivastava B D, Srivastava M, Srivastav S K, Suzuki N, Srivastav A K. Cypermethrin-Induced Liver Histopathology in Rat: Protective Role of Jamun Seed and Orange Peel Extracts. IJT. 2018; 12 (4) :25-30
URL: http://ijt.arakmu.ac.ir/article-1-689-en.html


Volume 12, Issue 4 (July-August 2018) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
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