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Volume 2, Issue 3 (Autumn 2009)
IJT 2009, 2(3): 211-215 |
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Ranjbar A, Salehidoost R, Baeeri M, Abdollahi M. Pentoxifylline Attenuates Malathion-Induced Oxidative Damage in Rat. IJT 2009; 2 (3) :211-215
URL: http://ijt.arakmu.ac.ir/article-1-70-en.html
URL: http://ijt.arakmu.ac.ir/article-1-70-en.html
1- Department of Toxicology, Hamedan University of Medical Sciences, H amedan, Iran , a.rangbar@yahoo.com
2- Shariati Hospital Tehran University of Medical sciences, Tehran. Iran
3- Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center
2- Shariati Hospital Tehran University of Medical sciences, Tehran. Iran
3- Laboratory of Toxicology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center
Abstract: (11426 Views)
Introduction: Toxic effects of pesticides are commonly associated with reactive oxygen species damage and pentoxifylline a phosphodiesterase inhibitor is a drug well known for antioxidant properties. The purpose of this study was to evaluate the oxidative damages following a subacute exposure to malathion, an organophosphorus insecticide and pentoxifylline's ability to counteract these effects.
Material and Methods: Malathion (200 mg/kg/day) and pentoxifylline (50 mg/kg/day) alone or in combination were administered intraperitoneally to rats and after one week, total antioxidant capacity (TAC) and total thiol groups (TTG) were measured in their blood.
Results: Pentoxifylline increased total antioxidant capacity (TAC) and total thiol groups (TTG) in blood significantly compared to malathion which decreased them.
Conclusion: Our findings suggest that oxidative stress occurs in exposure to malathion and oxidative damage may be a contributory factor in complications associated with malathion. The results indicate that malathion exposure decreases TAC and TTG, a process involved in oxidative stress and pentoxifylline could prevent this damage.
Material and Methods: Malathion (200 mg/kg/day) and pentoxifylline (50 mg/kg/day) alone or in combination were administered intraperitoneally to rats and after one week, total antioxidant capacity (TAC) and total thiol groups (TTG) were measured in their blood.
Results: Pentoxifylline increased total antioxidant capacity (TAC) and total thiol groups (TTG) in blood significantly compared to malathion which decreased them.
Conclusion: Our findings suggest that oxidative stress occurs in exposure to malathion and oxidative damage may be a contributory factor in complications associated with malathion. The results indicate that malathion exposure decreases TAC and TTG, a process involved in oxidative stress and pentoxifylline could prevent this damage.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
