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Volume 2, Issue 3 (Autumn 2009)
IJT 2009, 2(3): 228-233 |
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Talaie H, Abdollahi M, Pajoumand A, Panahandeh R, Barari B, Baeeri M. Alteration of Serum Levels of Interlukin 1 and Tumor Necrosis Factor in Depression Independent of Treatment or Overdose of Tricyclic Antidepressants. IJT 2009; 2 (3) :228-233
URL: http://ijt.arakmu.ac.ir/article-1-73-en.html
URL: http://ijt.arakmu.ac.ir/article-1-73-en.html
Hale Talaie * 
1, Mohammad Abdollahi2 , Abdolkarim Pajoumand3 , Reyhaneh Panahandeh3 , Behjat Barari4 , Maryam Baeeri
1, Mohammad Abdollahi2 , Abdolkarim Pajoumand3 , Reyhaneh Panahandeh3 , Behjat Barari4 , Maryam Baeeri
1- Toxicological ResearchCenter, Longhman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , talaie@sbmu.ac.ir
2- Faculty of Pharmacy, and Phramaceutical sciences Research Center, Tehran University of Medical Sciences,Tehran, Iran
3- Toxicological ResearchCenter, Longhman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Poison Center, Loghman-Hakim Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
2- Faculty of Pharmacy, and Phramaceutical sciences Research Center, Tehran University of Medical Sciences,Tehran, Iran
3- Toxicological ResearchCenter, Longhman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Poison Center, Loghman-Hakim Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
Abstract: (8365 Views)
Introduction: Pro-inflammatory cytokines, such as IL-1b and TNF- α have been suggested to be involved in the pathophysiology of depression. Tricyclic antidepressants (TCAs) are also thought to influence immune functions and concentrations of cytokines. The aim of this study was to evaluate the status of serum IL-1b and TNF-α in depressed patients who were treated, not treated, or poisoned with TCAs in comparison to healthy subjects.
Material & Methods: In this cross-sectional study, 40 patients who were admitted at Loghman-Hakim Hospital from August 2007 to January 2008 were selected. They were divided into 4 groups: healthy individuals, TCA-poisoned patients, TCA-treated depressed patients, and non-treated depressed patients with 10 subjects in each group. Serum level of IL-1b and TNF-α were compared between groups and demographic and clinical data were collected by a questioner filled out by a trained practitioner. Liver function tests, blood cell count, electrocardiography, and arterial blood gases were also performed.
Results: Complete blood analysis and demographic data showed significant differences between groups. IL-1b level was higher among females. The group of depressed patients non-treated with TCAs showed higher serum concentrations of IL-1b and TNF-α than other groups. No significant difference was observed in IL-1b and TNF-α values among healthy control, depressed TCA-treated, and TCA-poisoned groups.
Conclusion: Depression and gender may influence the production of cytokines while neither TCAs treatment nor its overdose affects IL-1b and TNF-α.
Material & Methods: In this cross-sectional study, 40 patients who were admitted at Loghman-Hakim Hospital from August 2007 to January 2008 were selected. They were divided into 4 groups: healthy individuals, TCA-poisoned patients, TCA-treated depressed patients, and non-treated depressed patients with 10 subjects in each group. Serum level of IL-1b and TNF-α were compared between groups and demographic and clinical data were collected by a questioner filled out by a trained practitioner. Liver function tests, blood cell count, electrocardiography, and arterial blood gases were also performed.
Results: Complete blood analysis and demographic data showed significant differences between groups. IL-1b level was higher among females. The group of depressed patients non-treated with TCAs showed higher serum concentrations of IL-1b and TNF-α than other groups. No significant difference was observed in IL-1b and TNF-α values among healthy control, depressed TCA-treated, and TCA-poisoned groups.
Conclusion: Depression and gender may influence the production of cytokines while neither TCAs treatment nor its overdose affects IL-1b and TNF-α.
Keywords: Tricyclic Antidepressants, Poisoning, Interleukins, Tumor Necrosis Factor-alpha, Cytokines
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
