Morteza Rahbar Taromsari, Alireza Badsar, Keyvan Aminian, Habib Allah Abiar, Morteza Fallah Karkan, Sina Montazeri, Keyvan Abbasi,
Volume 7, Issue 22 (Autumn 2013)
Abstract
Background: Caustics produce one of the most serious complications of poisonings. This research was aimed to study demographical, clinical and endoscopic findings in patients with corrosive injury.
Methods: In a retrospective survey, all records of the patients who had been admitted to Razi and 17th Shahrivar hospital in Rasht city due to the ingestion of caustic agents during 2002-2009 and endoscopy had been performed for them in the first 24 hours after ingestion were studied. The information was analyzed by descriptive method using SPSS 16 software.
Results: Among 258 patients in Razi Hospital, 174 (67.4%) were female with mean age of 29.33 years old. 127 patients (61.1%) had intentional ingestion. 208 patients were finally studied. Among them, 175 patients were hospitalized for 2 days (average 1.73 days). Among 45 patients of 17th Shahrivar hospital, 24 (53.3%) were female. All of them had accidental ingestion. The most frequent site of injury in adults was esophagus (37.2%) and in pediatric population was the mouth (66.6%). Of all pediatric patients, one case had grade IIb endoscopic injury. Among cases who underwent endoscopy (in adults),20.8%, 16.7%, 41.6%, 16.7%,4.2% had grade zero, I, IIa, IIb and III injury, respectively .In all cases, bleaches were the most frequent consumed material.
Conclusion: In both studied groups, female patients were more affected by corrosive agents and in adults, intentional ingestion was approximately 1.5 times more frequent than the accidental cases while all of pediatric patients had accidental poisoning. Most of the lesions had been received only medical treatment without any surgical interventions.
Mr Hamed Abbasi, Dr Golnaz Asaadi Tehrani, Dr Masoumeh Asle-Rousta,
Volume 18, Issue 4 (Octobr 2024)
Abstract
Background: The signaling pathway of the transforming growth factor (TGF)-β/SMAD3 plays a crucial role in developing liver and kidney fibrosis. TGF-β is linked to metastasis through SRY-related, high-mobility box (SOX-2). The objective of this study was to investigate the impact of thymol and menthol, two monoterpene compounds, on the SOX-2 expression and TGF-β/SMAD3 signaling in the liver and kidneys of mice after administering diethylnitrosamine (DEN).
Methods: The Balb/C male mice, aged 14 days, were administered a single intraperitoneal injection of DEN (25 mg/kg) and then given daily either thymol (10 mg/kg) or menthol (50 mg/kg) for 26 consecutive weeks. The mRNA levels of TGF-β, SMAD3, and SOX-2 were measured after 4 and 26 weeks of treatment.
Results: The administration of DEN increased the expressions of TGF-β, SMAD3, and SOX-2 in the liver of animals after 4 and 26 weeks; however, their expressions in the kidneys increased only at the end of the 26th week compared to that of the control group. Thymol and menthol inhibited the expression of TGF-β, SMAD3, and SOX-2 in the liver and kidneys of the mice injected with DEN.
Conclusion: Based on the study findings, we concluded that thymol and menthol prevented carcinogenesis induction via expression of DEN in the liver and kidneys by inhibiting the associated expression of epithelial-mesenchymal transition and SOX-2.
