Write your message

Search published articles


Showing 2 results for Dada

Elham Zadeh Hashem, Mohammad Kazem Koohi, Mohsen Eslami, Farzad Asadi, Reza Taleb Zadeh , Mina Khodadadi, Sepideh Hassani-Dizaj,
Volume 10, Issue 5 (September-October 2016)
Abstract

Background: Co-supplementation of unsaturated fatty acids (FAs) with saturated FAs may decrease the adverse effects of saturated FA-induced lipotoxicity. The objective of the present study was to evaluate the effect of palmitoleic acid (unsaturated fatty acid) on palmitic acid (saturated fatty acid) induced lipotoxicity criteria in the primary culture of adult rat cardiomyocytes.

Methods: Cells were treated with 0.5 mM palmitic acid, palmitoleic acid, palmitic + palmitoleic acids or remained untreated. The values of cellular triacylglycerol (TAG), diacylglycerol (DAG), DNA fragmentation and cellular viability were evaluated over 24 h, 48 h and 72 h time points.

Results: Co-administration of palmitic and palmitoleic acids increased TAG values over 48 h and 72 h time points compared to the palmitic acid (34.37% and 62.79%, respectively; P <0.001), while decreased DAG values (18.85% and 29.42%, respectively; P <0.01). Moreover, palmitoleic acid decreased DNA fragmentation and increased viability when administrated with palmitic acid (P <0.05).

Conclusion: Palmitoleic acid may be beneficial for diminishing adverse effects of palmitic acid in the rat cardiomyocytes through alterations in the molecule signaling levels. 


Kosisochukwu Arinze, Olufemi Amole, Adeyemi Dada, Abdulfatai Ojewale, Edobor Emiogun, Omoniyi Yemitan,
Volume 19, Issue 3 (4-2025)
Abstract

Background: Carica papaya plant parts have been documented for treating liver injuries in ethnomedicine despite the limited comparison of the anti-hepatotoxic properties of individual parts. This study compared the antihepatotoxic effects of hydroethanol leaf extract of C. papaya (HELC) and aqueous unripe fruit extract of C. papaya (AUFC) against paracetamol-induced hepatotoxicity in rats.
Methods: Thirty male rats were randomly allotted to six groups (n = 5). Liver injury was induced by paracetamol (600 mg/kg, p.o.) in all groups except the normal group. Then, HELC or AUFC was administered at 200 mg/kg and 400 mg/kg to each group at 2, 6, and 10 h. Twenty-four hours later, blood samples were collected to evaluate the serum levels of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), and uric acid and confirmed by histopathological examination of the liver tissue.
Results: A significant (P<0.05) and dose-dependent reduction in the ALT, AST, and uric acid serum levels in the HELC and AUFC treatment groups compared with the control.  Serum levels of the markers were generally lowered at 400 mg/kg rather than 200 mg/kg for each of HELC and AUFC. However, no statistically significant dose-dependent values were recorded. Also, at 400 mg/kg, HELC produced the highest reduction of the markers among all treatment groups, confirmed by histopathological findings.
Conclusion: Both HELC and AUFC showed antihepatotoxic effects. At higher doses, HELC produced a greater antihepatotoxic effect than AUFC. However, these comparative effects were not statistically significant.


Page 1 from 1     

© 2025 CC BY-NC 4.0 | Iranian Journal of Toxicology

Designed & Developed by : Yektaweb