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The Report of Suicide by Ingestion of Lidocaine Topical Spray
Hossein Hassanian-Moghaddam, Kambiz Soltaninejad, Ahmad Ghoochani, Vahid-Reza Mohebpour, Shahin Shadnia,
Volume 8, Issue 24 (Spring 2014)
Abstract
Background: Lidocaine is a local anesthetic and antiarrhythmic agent. There are reports on accidental and intentional cases of poisoning following injection of lidocaine while rare are the fatal cases realized after oral ingestion of lidocaine. Suicidal poisoning with lidocaine pharmaceutical formulations is rare since no pharmaceutical dosage forms for oral use are available except gels and sprays used as local anesthetics in dentistry.
Cases: Three cases of suicidal poisoning by ingestion of the content of lidocaine topical spray are reported in the present study. The cases developed episodes of seizure requiring diazepam and other therapeutic modalities upon admission. Eventually, one of the cases expired.
  Conclusion: To the best of our knowledge, this study is the first reported case of suicidal poisoning after ingestion of this formulation which highlights the fact that lidocaine topical spray formulation may be used for committing suicide. Ingestion of lidocaine present in topical spray can induce varying levels of toxicity that can even be fatal.

Predictive Factors of Gastrointestinal Injuries after Exposure to Sodium Hypochlorite
Ahmad Ghoochani Khorasani , Peyman Erfantalab, Mahdi Rezai ,
Volume 11, Issue 3 (May-June 2017)
Abstract

Background: Sodium hypochlorite is found in bleaching agents used to cleaning dishes and bleach laundry. The ingestion of sodium hypochlorite causes acute corrosive esophagitis and gastritis. In establishing the diagnosis and therapeutic approach of acute corrosive poisonings, the upper endoscopy has great importance. The aim of this study was to determine predictive factors of gastrointestinal injuries that mandate early endoscopy.

Methods: This study consisted of 65 patients presented to Loghman Hakim Toxicology Center, Tehran, Iran with history of sodium hypochlorite bleach exposure from 2010 to 2014. The post-corrosive damage classified according to Kikendal’s grading.

Results: There were a total of 19 males and 46 females with a mean age of 34.21 yr old. In upper GI endoscopy, 20% of poisoned patients had abnormal findings. Male gender (P=0.029), presence of hoarseness (P=0.044), nausea and vomiting (P=0.007), sialorrhea (P=0.044) and higher age (P=0.05) were associated with the occurrence of gastrointestinal injuries, but only male gender (OR=5.04), nausea and vomiting (OR=8.97) were independent predictors of gastrointestinal injuries (P=0.03 and P=0.03, respectively).

Conclusion: We proposed five factors associated with gastrointestinal injuries, which could be important factors that mandate urgent endoscopy.


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