Showing 3 results for Transaminases
Alireza Badsar, Morteza Rahbar Taramsari, Alireza Amir Maafi, Melina Rouhi Rad, Gelayol Chatrnour, Sina Khajeh Jahromi,
Volume 7, Issue 20 (4-2013)
Abstract
Background: Mushroom poisoning as a medical emergency can be a challenging problem for physicians. Despite the vast resources of poisonous mushrooms in Iran, few studies have been done in this regard, especially in the southwest region of the Caspian Sea that is very suitable for mushroom growth. Therefore, the aim of this study was to evaluate our experience with mushroom poisoning in this region.
Methods: This retrospective study reviewed the records of 102 patients who were admitted to the Emergency Department of Razi Hospital of Rasht, the only referral department in this region, from May 2006 to May 2011. Data were analyzed by Chi-square test, ANOVA, and student’s t-test.
Results: The patients’ age ranged from 13 to 75 years and 47 of them were male and the rest 55 were female. Overall, 57.8% of mushroom poisoning cases occurred in patients from urban areas. Most incidences were reported between September and October, the rainy season in Guilan. Except for four patients with tachycardia, others had stable vital signs. The most frequent symptoms (86.4%) were nausea and vomiting. Complete blood cell count revealed that 28.4% of the patients had leukocytosis but all of them had platelet counts of less than 100000.
Conclusions: This study showed that all cases had mild to moderate symptoms that were treated by simple supportive therapies. This suggested that mushroom species in our region are less dangerous but further studies need to establish what toxins and species are responsible for mushroom toxicity.
Morteza Rahbar Taramsari, Alireza Badsar, Afshin Shafaghi, Maryam Namakchian Namakin, Hannan Ebrahimi, Morteza Fallah Karkan,
Volume 7, Issue 21 (5-2013)
Abstract
Background: Aluminum phosphide (ALP) or rice tablet is a common agent used as pesticides. It is cheap, widely available and highly toxic and responsible for many cases of poisoning in the agricultural communities. There is limited evidence about change of liver enzymes in patients with ALP poisoning in this region. Therefore, we decided to evaluate alteration of liver enzymes in ALP poisoning in Rasht.
Methods: In this retrospective cross-sectional study, all documents of patients with ALP poisoning admitted to Razi hospital of Rasht in 2008-2009 were assessed. Inclusion criteria were diagnostic clinical manifestation such as hypotension or metabolic acidosis, history of exposure to ALP during the past 24 hours and progressive signs and symptoms despite treatment (administration of sodium bicarbonate and vasopressor). Patients with past history of hepatic disease were excluded. Collected data were analyzed with SPSS software.
Results: Of 104 patients with ALP poisoning, 66 patients (63.5%) were men. The mean age was 33.8±14.69 years, and the mean time of hospitalization was 14.94±18.28 hours. Ninety-five patients (91.3%) needed ventilation and 93 patients (89.4%) died. Statistical analysis demonstrated that elevated liver enzymes were not significantly related with gender, age, time of admission, time of hospitalization, the need for ventilation and mortality.
Conclusion: It seems that liver enzymes changes is not seen widely in ALP poisoning and had lower importance than other complications. Because of limited studies in liver enzyme alterations in these patients, it is suggested that more studies with largee sample size is performed to investigate the ALP liver side effects.
Bita Dadpour , Reza Afshari , Seyed Reza Mousavi, Sina Kianoush, Mohamad Reza Keramati, Vali Allah Moradi, Mahmood Sadeghi, Faezeh Madani Sani , Mahdi Balali Mood,
Volume 10, Issue 2 (2-2016)
Abstract
Background: Occupational lead poisoning is common in workers of some industries, but lead hepatotoxicity has rarely been reported. Several animal studies have revealed lead induced liver damage but clinical studies concerning the manifestations of lead induced liver toxicity in humans are scares. This study was designed to investigate the clinical manifestations and pathological parameters of hepatic dysfunction and its relationship with blood and urine lead concentrations in a car battery-manufacturing workers.
Methods: This cross sectional study was carried out in Mashhad, Iran, during April-June 2011. One hundred and twelve workers underwent blood and urine sampling for determination of lead concentrations and liver function tests. Clinical signs and symptoms of possible lead hepatotoxicity were investigated.
Results: Mean (±SD) age of the workers was 28.78 (±5.17) yr with a daytime work of 8.67 (±1.41) h and mean work duration of 3.89 (±2.40) yr. Mean blood lead concentration (BLC) and urine lead concentration (ULC) were 398.95 (±177.41) µg/l and 83.67(±50) μg/l, respectively. We found no correlation between the clinical findings and BLC or ULC. A weak correlation (R: 0.27, P=0.087) between serum alkaline phosphatase concentration and BLC was obtained. No significant relationship was found between other liver function tests and BLC or ULC.
Conclusion: We found no specific clinical and laboratory abnormalities of liver in the workers of car battery manufacturer who had chronic lead toxicity. Further investigations with more specific laboratory tests such as LDH5 and gamma glutamyl transferase (GGT) as well as novel biomarkers of metal induced hepatotoxicity might be helpful in evaluating lead hepatotoxicity.
