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Volume 6, Issue 16 (Spring 2012)
IJT 2012, 6(16): 588-593 |
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Behnoush B, Taghadosinejad F, Arefi M, Shahabi M, Jamalian M, Kazemifar A M. Prevalence and Complications of Drug-induced Seizures in Baharloo Hospital, Tehran, Iran. IJT 2012; 6 (16) :588-593
URL: http://ijt.arakmu.ac.ir/article-1-118-en.html
URL: http://ijt.arakmu.ac.ir/article-1-118-en.html
Behnam Behnoush1 
, Fakhredin Taghadosinejad1 , Mohammad Arefi1 , Mohsen Shahabi * 2, Mohammad Jamalian3 , Amir Mohammad Kazemifar4
, Fakhredin Taghadosinejad1 , Mohammad Arefi1 , Mohsen Shahabi * 2, Mohammad Jamalian3 , Amir Mohammad Kazemifar4
1- Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran , Mohshahabi@gmail.com
3- Department of Forensic Medicine and Toxicology, Arak University of Medical Sciences, Tehran, Iran
4- Department of Forensic Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
2- Department of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran , Mohshahabi@gmail.com
3- Department of Forensic Medicine and Toxicology, Arak University of Medical Sciences, Tehran, Iran
4- Department of Forensic Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
Abstract: (12546 Views)
ABSTRACT
Background: Seizure is a frequent and important finding in the field of clinical toxicology. Almost all poisons and drugs can produce seizure. We have evaluated frequency and complications of drug-induced seizure in present study.
Methods: The present descriptive cross-sectional study was done on patients who were referred to Baharloo Hospital, Tehran, Iran, that had developed seizure before or after hospitalization following intoxication between 20 March 2010 and 20 March 2011. The exclusion criteria were a positive history of epilepsy, head trauma, or abnormal findings in EEG or brain CT scan.
Results: Tramadol and tricyclic antidepressants were the most common causes of drug-induced seizure (31.5% and 14.7% of the cases, respectively). Overall, 6 patients (4.2%) had developed persistent vegetative state in consequence of brain hypoxia, 16 patients (11.2%) had died due to complications of seizure or the poisoning itself. Tramadol was the leading cause of drug-induced seizure and its morbidity and mortality. Tonic-colonic seizure was the most common type of drug-induced seizure. Seizure had occurred once in 58% of the patients, twice in 37.1% of the patients, and had been revolutionized to status epilepticus in 4.9% of them. Among the 7 patients who had developed status epilepticus, 3 cases had died.
Conclusion: Appropriate measures for treatment of seizure and prevention of its complications should be taken when patients with drug poisoning are admitted into hospital, especially when the offending drug(s) has a higher likelihood to induce seizure.
Background: Seizure is a frequent and important finding in the field of clinical toxicology. Almost all poisons and drugs can produce seizure. We have evaluated frequency and complications of drug-induced seizure in present study.
Methods: The present descriptive cross-sectional study was done on patients who were referred to Baharloo Hospital, Tehran, Iran, that had developed seizure before or after hospitalization following intoxication between 20 March 2010 and 20 March 2011. The exclusion criteria were a positive history of epilepsy, head trauma, or abnormal findings in EEG or brain CT scan.
Results: Tramadol and tricyclic antidepressants were the most common causes of drug-induced seizure (31.5% and 14.7% of the cases, respectively). Overall, 6 patients (4.2%) had developed persistent vegetative state in consequence of brain hypoxia, 16 patients (11.2%) had died due to complications of seizure or the poisoning itself. Tramadol was the leading cause of drug-induced seizure and its morbidity and mortality. Tonic-colonic seizure was the most common type of drug-induced seizure. Seizure had occurred once in 58% of the patients, twice in 37.1% of the patients, and had been revolutionized to status epilepticus in 4.9% of them. Among the 7 patients who had developed status epilepticus, 3 cases had died.
Conclusion: Appropriate measures for treatment of seizure and prevention of its complications should be taken when patients with drug poisoning are admitted into hospital, especially when the offending drug(s) has a higher likelihood to induce seizure.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
