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Volume 17, Issue 2 (May 2023)
IJT 2023, 17(2): 147-156 |
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Akorede G J, Ambali S F, Olatunji A O, Aremu A, Ahmed A O, Basiru A, et al . Vitamin C Protects Against Blood and Thyroid Toxicities Induced by the Chronic Use of Carbamazepine in Rats. IJT 2023; 17 (2) :147-156
URL: http://ijt.arakmu.ac.ir/article-1-1209-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1209-en.html
Ganiu Jimoh Akorede * 
1, Suleiman Folorunsho Ambali2 , Aisha Omobolanle Olatunji2 , Abdulfatai Aremu2 , Akeem Olayiwola Ahmed3 , Afisu Basiru4 , Mistura Oyebisi Azeez4 , Fatima Sanusi4 , Rafiu Adebisi Kadir5 , Isiaku Abdulmajeed5
1, Suleiman Folorunsho Ambali2 , Aisha Omobolanle Olatunji2 , Abdulfatai Aremu2 , Akeem Olayiwola Ahmed3 , Afisu Basiru4 , Mistura Oyebisi Azeez4 , Fatima Sanusi4 , Rafiu Adebisi Kadir5 , Isiaku Abdulmajeed5
1- Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ilorin. Ilorin, Nigeria. , akorede.gj@unilorin.edu.ng
2- Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ilorin. Ilorin, Nigeria.
3- Department of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Ilorin. Ilorin, Nigeria.
4- Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.
5- Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.
2- Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ilorin. Ilorin, Nigeria.
3- Department of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Ilorin. Ilorin, Nigeria.
4- Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.
5- Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ilorin, Ilorin, Nigeria.
Abstract: (1168 Views)
Background: Drugs are the mainstay of the clinical management of epilepsy. Carbamazepine (CBZ) is commonly used for treating epilepsy and neuropathic pain. This drug has been reported to have toxic effects on the hematological system due to its induction of oxidative stress. This study aimed to investigate the protective effects of vitamin C against hematological and thyroid toxicities caused by the chronic use of carbamazepine in male Wistar rats.
Methods: Thirty-two adult Wistar rats were categorized randomly into four groups of eight rats each and treated as follows: Group 1 received distilled water (2 mL/kg); group 2 was treated with vitamin C (100 mg/kg); group 3 received carbamazepine (20 mg/kg), and group 4 was pre-treated with vitamin C (100 mg/kg) and given carbamazepine (20 mg/kg) 30 min later. All treatments were administered via gavage once per day over fifteen consecutive weeks. The rats’ blood samples were tested for changes in hematological parameters while the sera were evaluated for liver biochemical enzymes and thyroid hormone levels.
Results: The results revealed that pre-treatment with vitamin C protected against alterations in parameters associated with hematological and thyroid toxicities.
Conclusion: Based on the study results, it was concluded that: a) The chronic use of CBZ caused hematological and thyroid toxicities, and b) Vitamin C protected against these toxicities. Therefore, it is highly likely that vitamin C has the potential to protect experimental animals against injuries induced by CBZ to the liver, blood cells, and hypothalamic-pituitary-thyroid axis in a Wistar rat model.
Methods: Thirty-two adult Wistar rats were categorized randomly into four groups of eight rats each and treated as follows: Group 1 received distilled water (2 mL/kg); group 2 was treated with vitamin C (100 mg/kg); group 3 received carbamazepine (20 mg/kg), and group 4 was pre-treated with vitamin C (100 mg/kg) and given carbamazepine (20 mg/kg) 30 min later. All treatments were administered via gavage once per day over fifteen consecutive weeks. The rats’ blood samples were tested for changes in hematological parameters while the sera were evaluated for liver biochemical enzymes and thyroid hormone levels.
Results: The results revealed that pre-treatment with vitamin C protected against alterations in parameters associated with hematological and thyroid toxicities.
Conclusion: Based on the study results, it was concluded that: a) The chronic use of CBZ caused hematological and thyroid toxicities, and b) Vitamin C protected against these toxicities. Therefore, it is highly likely that vitamin C has the potential to protect experimental animals against injuries induced by CBZ to the liver, blood cells, and hypothalamic-pituitary-thyroid axis in a Wistar rat model.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
